BDBM429899 US10538496, Compound II-5

SMILES: ONC(=O)c1cccc2CC3(CCN(Cc4ccc(c(F)c4)C(F)(F)F)C3=O)Cc12

InChI Key: InChIKey=AXRLRINTGICCGI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 429899   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 11 (Homo sapiens (Human))	BDBM429899 (US10538496, Compound II-5) Show SMILES ONC(=O)c1cccc2CC3(CCN(Cc4ccc(c(F)c4)C(F)(F)F)C3=O)Cc12 Show InChI InChI=1S/C21H18F4N2O3/c22-17-8-12(4-5-16(17)21(23,24)25)11-27-7-6-20(19(27)29)9-13-2-1-3-14(15(13)10-20)18(28)26-30/h1-5,8,30H,6-7,9-11H2,(H,26,28)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
FORMA Therapeutics, Inc.; H. Lee Moffitt Cancer Center and Research Institute, Inc. US Patent					Assay Description The probe binding HDAC11 assay was performed using a time resolved fluorescence (TRF) assay format. Recombinant N-terminal GST tag full-length human ...				US Patent US10538496 (2020) BindingDB Entry DOI: 10.7270/Q24J0HJR
					More data for this Ligand-Target Pair