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SMILES: Cn1ccc(COc2cnc(cc2-c2ccc(F)cc2)C(N)=O)n1

InChI Key: InChIKey=SSSNPJKQBYVHBV-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 430126   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM430126 (4-(4-fluorophenyl)-5-((1-methyl-1H-pyrazol-3-yl)me...) Show SMILES Cn1ccc(COc2cnc(cc2-c2ccc(F)cc2)C(N)=O)n1 Show InChI InChI=1S/C17H15FN4O2/c1-22-7-6-13(21-22)10-24-16-9-20-15(17(19)23)8-14(16)11-2-4-12(18)5-3-11/h2-9H,10H2,1H3,(H2,19,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE UniChem	US Patent	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University US Patent					Assay Description Gα15 HEK293 cells stably expressing rat mGlu2 were plated in black-walled, clear-bottomed, poly-D-lysine coated 384-well plates in 20 μL of assay m...				US Patent US10538491 (2020) BindingDB Entry DOI: 10.7270/Q2GT5QKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM430126 (4-(4-fluorophenyl)-5-((1-methyl-1H-pyrazol-3-yl)me...) Show SMILES Cn1ccc(COc2cnc(cc2-c2ccc(F)cc2)C(N)=O)n1 Show InChI InChI=1S/C17H15FN4O2/c1-22-7-6-13(21-22)10-24-16-9-20-15(17(19)23)8-14(16)11-2-4-12(18)5-3-11/h2-9H,10H2,1H3,(H2,19,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu3R (unknown origin)				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM430126 (4-(4-fluorophenyl)-5-((1-methyl-1H-pyrazol-3-yl)me...) Show SMILES Cn1ccc(COc2cnc(cc2-c2ccc(F)cc2)C(N)=O)n1 Show InChI InChI=1S/C17H15FN4O2/c1-22-7-6-13(21-22)10-24-16-9-20-15(17(19)23)8-14(16)11-2-4-12(18)5-3-11/h2-9H,10H2,1H3,(H2,19,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE UniChem	Article PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu2R (unknown origin)				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM430126 (4-(4-fluorophenyl)-5-((1-methyl-1H-pyrazol-3-yl)me...) Show SMILES Cn1ccc(COc2cnc(cc2-c2ccc(F)cc2)C(N)=O)n1 Show InChI InChI=1S/C17H15FN4O2/c1-22-7-6-13(21-22)10-24-16-9-20-15(17(19)23)8-14(16)11-2-4-12(18)5-3-11/h2-9H,10H2,1H3,(H2,19,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu4R (unknown origin)				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM430126 (4-(4-fluorophenyl)-5-((1-methyl-1H-pyrazol-3-yl)me...) Show SMILES Cn1ccc(COc2cnc(cc2-c2ccc(F)cc2)C(N)=O)n1 Show InChI InChI=1S/C17H15FN4O2/c1-22-7-6-13(21-22)10-24-16-9-20-15(17(19)23)8-14(16)11-2-4-12(18)5-3-11/h2-9H,10H2,1H3,(H2,19,23)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu6R (unknown origin)				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 7 (Homo sapiens (Human))	BDBM430126 (4-(4-fluorophenyl)-5-((1-methyl-1H-pyrazol-3-yl)me...) Show SMILES Cn1ccc(COc2cnc(cc2-c2ccc(F)cc2)C(N)=O)n1 Show InChI InChI=1S/C17H15FN4O2/c1-22-7-6-13(21-22)10-24-16-9-20-15(17(19)23)8-14(16)11-2-4-12(18)5-3-11/h2-9H,10H2,1H3,(H2,19,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu7R (unknown origin)				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM430126 (4-(4-fluorophenyl)-5-((1-methyl-1H-pyrazol-3-yl)me...) Show SMILES Cn1ccc(COc2cnc(cc2-c2ccc(F)cc2)C(N)=O)n1 Show InChI InChI=1S/C17H15FN4O2/c1-22-7-6-13(21-22)10-24-16-9-20-15(17(19)23)8-14(16)11-2-4-12(18)5-3-11/h2-9H,10H2,1H3,(H2,19,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu1R (unknown origin)				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM430126 (4-(4-fluorophenyl)-5-((1-methyl-1H-pyrazol-3-yl)me...) Show SMILES Cn1ccc(COc2cnc(cc2-c2ccc(F)cc2)C(N)=O)n1 Show InChI InChI=1S/C17H15FN4O2/c1-22-7-6-13(21-22)10-24-16-9-20-15(17(19)23)8-14(16)11-2-4-12(18)5-3-11/h2-9H,10H2,1H3,(H2,19,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu8R (unknown origin)				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM430126 (4-(4-fluorophenyl)-5-((1-methyl-1H-pyrazol-3-yl)me...) Show SMILES Cn1ccc(COc2cnc(cc2-c2ccc(F)cc2)C(N)=O)n1 Show InChI InChI=1S/C17H15FN4O2/c1-22-7-6-13(21-22)10-24-16-9-20-15(17(19)23)8-14(16)11-2-4-12(18)5-3-11/h2-9H,10H2,1H3,(H2,19,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of mGlu5R (unknown origin)				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266
					More data for this Ligand-Target Pair