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SMILES: Cc1cc(ccc1OC1CCc2cccc(c12)-c1cccc(n1)-n1ncc(C(O)=O)c1C(F)(F)F)C1CCN(CC1)C(=O)C1CC1

InChI Key: InChIKey=ZPQUBWSSWCZJJM-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 430739   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM430739
PNG
(US10550102, Example 3a)
Show SMILES Cc1cc(ccc1OC1CCc2cccc(c12)-c1cccc(n1)-n1ncc(C(O)=O)c1C(F)(F)F)C1CCN(CC1)C(=O)C1CC1
Show InChI InChI=1S/C35H33F3N4O4/c1-20-18-24(21-14-16-41(17-15-21)33(43)23-8-9-23)11-12-28(20)46-29-13-10-22-4-2-5-25(31(22)29)27-6-3-7-30(40-27)42-32(35(36,37)38)26(19-39-42)34(44)45/h2-7,11-12,18-19,21,23,29H,8-10,13-17H2,1H3,(H,44,45)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1n/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....

US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair