BDBM430862 US10550102, Example 9. b). (+)

SMILES: Cc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O

InChI Key: InChIKey=KMZIJZGAFPSODO-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 430862   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430862 (US10550102, Example 9. b). (+)) Show SMILES Cc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O Show InChI InChI=1S/C34H35N5O3/c1-21-28(34(41)42)20-35-39(21)31-7-3-6-29(37-31)27-5-2-4-24-12-15-30(32(24)27)36-26-13-10-22(11-14-26)23-16-18-38(19-17-23)33(40)25-8-9-25/h2-7,10-11,13-14,20,23,25,30,36H,8-9,12,15-19H2,1H3,(H,41,42)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
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