BDBM430865 US10550102, Example 5-1

SMILES: Cc1cc2CCC(Oc3ccc4CN(Cc5ccccn5)CCc4c3)c2c(c1)-c1cccc(n1)-n1ncc(C(O)=O)c1C(F)(F)F

InChI Key: InChIKey=CMOKNYBSBSDAJV-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 430865   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430865 (US10550102, Example 5-1) Show SMILES Cc1cc2CCC(Oc3ccc4CN(Cc5ccccn5)CCc4c3)c2c(c1)-c1cccc(n1)-n1ncc(C(O)=O)c1C(F)(F)F Show InChI InChI=1S/C35H30F3N5O3/c1-21-15-23-9-11-30(46-26-10-8-24-19-42(14-12-22(24)17-26)20-25-5-2-3-13-39-25)32(23)27(16-21)29-6-4-7-31(41-29)43-33(35(36,37)38)28(18-40-43)34(44)45/h2-8,10,13,15-18,30H,9,11-12,14,19-20H2,1H3,(H,44,45)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	39	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
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