BDBM430869 US10550102, Example 5-3

SMILES: CCc1cc(O[C@H]2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2C(F)(F)F)ccc1C1CCN(CC1)C(=O)C1CC1

InChI Key: InChIKey=HMQMEEGPBGWFQL-PMERELPUSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 430869   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430869 (US10550102, Example 5-3) Show SMILES CCc1cc(O[C@H]2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2C(F)(F)F)ccc1C1CCN(CC1)C(=O)C1CC1 |r| Show InChI InChI=1S/C36H35F3N4O4/c1-2-21-19-25(12-13-26(21)22-15-17-42(18-16-22)34(44)24-9-10-24)47-30-14-11-23-5-3-6-27(32(23)30)29-7-4-8-31(41-29)43-33(36(37,38)39)28(20-40-43)35(45)46/h3-8,12-13,19-20,22,24,30H,2,9-11,14-18H2,1H3,(H,45,46)/t30-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair