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SMILES: OC(=O)c1cnn(c1C(F)(F)F)-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3)C3CCN(CC3)C(=O)C3CC3)c12

InChI Key: InChIKey=HUGMXQQOSVJRAB-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 430870   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM430870
PNG
(US10550102, Example 11-2)
Show SMILES OC(=O)c1cnn(c1C(F)(F)F)-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3)C3CCN(CC3)C(=O)C3CC3)c12
Show InChI InChI=1S/C34H32F3N5O3/c35-34(36,37)31-26(33(44)45)19-38-42(31)29-6-2-5-27(40-29)25-4-1-3-22-11-14-28(30(22)25)39-24-12-9-20(10-13-24)21-15-17-41(18-16-21)32(43)23-7-8-23/h1-6,9-10,12-13,19,21,23,28,39H,7-8,11,14-18H2,(H,44,45)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1n/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....

US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair