BDBM430871 US10550102, Example 5-4

SMILES: Cc1cc(ccc1O[C@H]1CCc2cccc(c12)-c1cccc(n1)-n1ncc(C(O)=O)c1C(F)(F)F)C1CCN(CC(F)(F)F)CC1

InChI Key: InChIKey=COIUJLKQOATJCQ-MHZLTWQESA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 430871   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430871 (US10550102, Example 5-4) Show SMILES Cc1cc(ccc1O[C@H]1CCc2cccc(c12)-c1cccc(n1)-n1ncc(C(O)=O)c1C(F)(F)F)C1CCN(CC(F)(F)F)CC1 |r| Show InChI InChI=1S/C33H30F6N4O3/c1-19-16-22(20-12-14-42(15-13-20)18-32(34,35)36)9-10-26(19)46-27-11-8-21-4-2-5-23(29(21)27)25-6-3-7-28(41-25)43-30(33(37,38)39)24(17-40-43)31(44)45/h2-7,9-10,16-17,20,27H,8,11-15,18H2,1H3,(H,44,45)/t27-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
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