BDBM430984 US10550102, Example 40-1 (-)

SMILES: CCC[C@H](O)C(=O)N1CCC(CC1)c1ccc(CC2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2CC)cc1CC

InChI Key: InChIKey=YYGCGAGADIUFIL-KEPYVBBOSA-N

Data: 1 EC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 430984   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430984 (US10550102, Example 40-1 (-)) Show SMILES CCC[C@H](O)C(=O)N1CCC(CC1)c1ccc(CC2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2CC)cc1CC |r| Show InChI InChI=1S/C39H46N4O4/c1-4-9-35(44)38(45)42-20-18-27(19-21-42)30-17-14-25(22-26(30)5-2)23-29-16-15-28-10-7-11-31(37(28)29)33-12-8-13-36(41-33)43-34(6-3)32(24-40-43)39(46)47/h7-8,10-14,17,22,24,27,29,35,44H,4-6,9,15-16,18-21,23H2,1-3H3,(H,46,47)/t29?,35-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
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