BDBM430987 US10550102, Example 61. b). (enantiomer-1)::US10550102, Example 61. b). (enantiomer-2)

SMILES: OC(=O)c1cnn(c1C(F)(F)F)-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C(F)(F)F)C3CCN(CC3)C(=O)C3CC3)c12

InChI Key: InChIKey=FYXNIIWCLPIUHE-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 430987   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430987 (US10550102, Example 61. b). (enantiomer-1) | US105...) Show SMILES OC(=O)c1cnn(c1C(F)(F)F)-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C(F)(F)F)C3CCN(CC3)C(=O)C3CC3)c12 Show InChI InChI=1S/C35H31F6N5O3/c36-34(37,38)25-17-22(19-13-15-45(16-14-19)32(47)21-7-8-21)10-11-27(25)43-28-12-9-20-3-1-4-23(30(20)28)26-5-2-6-29(44-26)46-31(35(39,40)41)24(18-42-46)33(48)49/h1-6,10-11,17-19,21,28,43H,7-9,12-16H2,(H,48,49)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430987 (US10550102, Example 61. b). (enantiomer-1) | US105...) Show SMILES OC(=O)c1cnn(c1C(F)(F)F)-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C(F)(F)F)C3CCN(CC3)C(=O)C3CC3)c12 Show InChI InChI=1S/C35H31F6N5O3/c36-34(37,38)25-17-22(19-13-15-45(16-14-19)32(47)21-7-8-21)10-11-27(25)43-28-12-9-20-3-1-4-23(30(20)28)26-5-2-6-29(44-26)46-31(35(39,40)41)24(18-42-46)33(48)49/h1-6,10-11,17-19,21,28,43H,7-9,12-16H2,(H,48,49)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair