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SMILES: CCC[C@H](O)C(=O)N1CCC(CC1)c1ccc(CC2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2CC)c(C)c1

InChI Key: InChIKey=NDTPANADGRIODZ-IPIVTTNMSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 430994   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM430994
PNG
(US10550102, Example 40-3 (+))
Show SMILES CCC[C@H](O)C(=O)N1CCC(CC1)c1ccc(CC2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2CC)c(C)c1 |r|
Show InChI InChI=1S/C38H44N4O4/c1-4-8-34(43)37(44)41-19-17-25(18-20-41)28-15-14-27(24(3)21-28)22-29-16-13-26-9-6-10-30(36(26)29)32-11-7-12-35(40-32)42-33(5-2)31(23-39-42)38(45)46/h6-7,9-12,14-15,21,23,25,29,34,43H,4-5,8,13,16-20,22H2,1-3H3,(H,45,46)/t29?,34-/m0/s1
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PC cid
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US Patent
n/an/an/an/a 0.5n/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....

US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair