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SMILES: CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Cc3ccc(C4CCN(CC4)C(=O)OC)c(CC)c3)c12)C(O)=O

InChI Key: InChIKey=IPPIMDIVVBVFRT-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 430996   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM430996
PNG
(US10550102, Example 41. b). (-))
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Cc3ccc(C4CCN(CC4)C(=O)OC)c(CC)c3)c12)C(O)=O
Show InChI InChI=1S/C36H40N4O4/c1-4-24-20-23(12-15-28(24)25-16-18-39(19-17-25)36(43)44-3)21-27-14-13-26-8-6-9-29(34(26)27)31-10-7-11-33(38-31)40-32(5-2)30(22-37-40)35(41)42/h6-12,15,20,22,25,27H,4-5,13-14,16-19,21H2,1-3H3,(H,41,42)
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PC cid
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US Patent
n/an/an/an/a 18n/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....

US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair