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SMILES: Cc1cc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c2c(c1)-c1cccc(n1)-n1ncc(C(O)=O)c1C(F)(F)F

InChI Key: InChIKey=ODHZMNOWYDDYOX-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 431004   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM431004
PNG
(US10550102, Example 43 (+))
Show SMILES Cc1cc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c2c(c1)-c1cccc(n1)-n1ncc(C(O)=O)c1C(F)(F)F
Show InChI InChI=1S/C36H36F3N5O3/c1-20-16-25-9-11-30(41-28-10-8-24(18-21(28)2)22-12-14-43(15-13-22)34(45)23-6-7-23)32(25)26(17-20)29-4-3-5-31(42-29)44-33(36(37,38)39)27(19-40-44)35(46)47/h3-5,8,10,16-19,22-23,30,41H,6-7,9,11-15H2,1-2H3,(H,46,47)
PDB
MMDB

UniProtKB/SwissProt

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PC cid
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US Patent
n/an/an/an/a 1n/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....

US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair