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BDBM431007 US10550102, Example 64-6

SMILES: CCc1c(cnn1-c1cccc(n1)-c1cccc2CC[C@H](Oc3ccc(C4CCN(CC4)C(=O)OCC4CC4)c(CC)c3)c12)C(O)=O

InChI Key: InChIKey=VFPRNERMRDTRGV-UMSFTDKQSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 431007   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Guanylate cyclase soluble subunit alpha-1/beta-1


(Homo sapiens (Human))		BDBM431007
PNG
(US10550102, Example 64-6)
Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CC[C@H](Oc3ccc(C4CCN(CC4)C(=O)OCC4CC4)c(CC)c3)c12)C(O)=O |r|
Show InChI InChI=1S/C38H42N4O5/c1-3-25-21-28(14-15-29(25)26-17-19-41(20-18-26)38(45)46-23-24-11-12-24)47-34-16-13-27-7-5-8-30(36(27)34)32-9-6-10-35(40-32)42-33(4-2)31(22-39-42)37(43)44/h5-10,14-15,21-22,24,26,34H,3-4,11-13,16-20,23H2,1-2H3,(H,43,44)/t34-/m0/s1
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PC cid
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US Patent
n/an/an/an/a 1.40n/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....

US Patent US10550102 (2020)


BindingDB Entry DOI: 10.7270/Q2PC34SQ
More data for this
Ligand-Target Pair