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SMILES: CNc1nc(Nc2cnn(C3C[C@@H]4C[C@@H]4C3)c2C)ncc1C(F)(F)F

InChI Key: InChIKey=HWUCJPOXWRTICF-ZACCUICWSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 436212   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Homo sapiens (Human))	BDBM436212 (US10590114, No. 4 | US11111235, No. 4) Show SMILES CNc1nc(Nc2cnn(C3C[C@@H]4C[C@@H]4C3)c2C)ncc1C(F)(F)F |r| Show InChI InChI=1S/C16H19F3N6/c1-8-13(7-22-25(8)11-4-9-3-10(9)5-11)23-15-21-6-12(16(17,18)19)14(20-2)24-15/h6-7,9-11H,3-5H2,1-2H3,(H2,20,21,23,24)/t9-,10+,11?	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM436212 (US10590114, No. 4 | US11111235, No. 4) Show SMILES CNc1nc(Nc2cnn(C3C[C@@H]4C[C@@H]4C3)c2C)ncc1C(F)(F)F |r| Show InChI InChI=1S/C16H19F3N6/c1-8-13(7-22-25(8)11-4-9-3-10(9)5-11)23-15-21-6-12(16(17,18)19)14(20-2)24-15/h6-7,9-11H,3-5H2,1-2H3,(H2,20,21,23,24)/t9-,10+,11?	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
Denali Therapautics Inc. US Patent					Assay Description Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...				US Patent US10590114 (2020)
					More data for this Ligand-Target Pair