null

SMILES: Cc1cc2n(cc(-c3cncc4NC(C)(C)C=Cc34)c2cc1C#N)[C@H]1CC[C@H](O)CC1

InChI Key: InChIKey=SPLNFCCMPUTMQI-WGSAOQKQSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 439100   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM439100 (US10604502, Ex # 88) Show SMILES Cc1cc2n(cc(-c3cncc4NC(C)(C)C=Cc34)c2cc1C#N)[C@H]1CC[C@H](O)CC1 |r,wU:24.27,wD:27.31,c:16,(-6.1,.69,;-4.64,1.16,;-3.49,.13,;-2.03,.61,;-.69,-.16,;.45,.87,;-.17,2.28,;.6,3.61,;-.17,4.94,;.6,6.28,;2.14,6.28,;2.91,4.94,;4.45,4.94,;5.22,3.61,;6.55,4.38,;6.55,2.84,;4.45,2.28,;2.91,2.28,;2.14,3.61,;-1.71,2.12,;-2.85,3.15,;-4.32,2.67,;-5.46,3.7,;-6.55,4.79,;-.53,-1.69,;.88,-2.3,;1.07,-3.82,;-.16,-4.75,;.02,-6.28,;-1.58,-4.14,;-1.76,-2.62,)| Show InChI InChI=1S/C26H28N4O/c1-16-10-25-21(11-17(16)12-27)23(15-30(25)18-4-6-19(31)7-5-18)22-13-28-14-24-20(22)8-9-26(2,3)29-24/h8-11,13-15,18-19,29,31H,4-7H2,1-3H3/t18-,19-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of twelve concentrations. The...				US Patent US10604502 (2020)
					More data for this Ligand-Target Pair