null

SMILES: CN1CCC(CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1cncc(F)c1

InChI Key: InChIKey=HEXAUFHFVWRLAS-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 442834   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442834 (US10653688, Compound 20) Show SMILES CN1CCC(CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1cncc(F)c1 Show InChI InChI=1S/C21H21FN4O/c1-26-6-4-14(5-7-26)21(27)25-20-10-17-8-15(2-3-16(17)12-24-20)18-9-19(22)13-23-11-18/h2-3,8-14H,4-7H2,1H3,(H,24,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	31	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM442834 (US10653688, Compound 20) Show SMILES CN1CCC(CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1cncc(F)c1 Show InChI InChI=1S/C21H21FN4O/c1-26-6-4-14(5-7-26)21(27)25-20-10-17-8-15(2-3-16(17)12-24-20)18-9-19(22)13-23-11-18/h2-3,8-14H,4-7H2,1H3,(H,24,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.28E+3	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Di...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair