null

SMILES: CC1CN(C[C@H]2CCC(CC2)C(=O)Nc2cc3cc(ccc3cn2)-c2cnccn2)C1

InChI Key: InChIKey=AEKITTGFSZDDIC-NZANSXMDSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 442891   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM442891 (US10653688, Compound 72) Show SMILES CC1CN(C[C@H]2CCC(CC2)C(=O)Nc2cc3cc(ccc3cn2)-c2cnccn2)C1 |r,wU:5.4,(18.27,1.92,;16.97,2.74,;15.28,2.68,;14.8,4.14,;13.34,4.62,;12,3.85,;12,2.31,;10.67,1.54,;9.34,2.31,;9.34,3.85,;10.67,4.62,;8,1.54,;6.67,2.31,;8,,;6.67,-.77,;5.33,,;4,-.77,;2.67,,;1.33,-.77,;1.33,-2.31,;2.67,-3.08,;4,-2.31,;5.33,-3.08,;6.67,-2.31,;;-1.33,-.77,;-2.67,,;-2.67,1.54,;-1.33,2.31,;,1.54,;16.34,4.14,)| Show InChI InChI=1S/C25H29N5O/c1-17-14-30(15-17)16-18-2-4-19(5-3-18)25(31)29-24-11-22-10-20(6-7-21(22)12-28-24)23-13-26-8-9-27-23/h6-13,17-19H,2-5,14-16H2,1H3,(H,28,29,31)/t18-,19?	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.22E+3	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Di...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM442891 (US10653688, Compound 72) Show SMILES CC1CN(C[C@H]2CCC(CC2)C(=O)Nc2cc3cc(ccc3cn2)-c2cnccn2)C1 |r,wU:5.4,(18.27,1.92,;16.97,2.74,;15.28,2.68,;14.8,4.14,;13.34,4.62,;12,3.85,;12,2.31,;10.67,1.54,;9.34,2.31,;9.34,3.85,;10.67,4.62,;8,1.54,;6.67,2.31,;8,,;6.67,-.77,;5.33,,;4,-.77,;2.67,,;1.33,-.77,;1.33,-2.31,;2.67,-3.08,;4,-2.31,;5.33,-3.08,;6.67,-2.31,;;-1.33,-.77,;-2.67,,;-2.67,1.54,;-1.33,2.31,;,1.54,;16.34,4.14,)| Show InChI InChI=1S/C25H29N5O/c1-17-14-30(15-17)16-18-2-4-19(5-3-18)25(31)29-24-11-22-10-20(6-7-21(22)12-28-24)23-13-26-8-9-27-23/h6-13,17-19H,2-5,14-16H2,1H3,(H,28,29,31)/t18-,19?	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10653688 (2020) BindingDB Entry DOI: 10.7270/Q2Z322PW
					More data for this Ligand-Target Pair