BDBM443440 US10654866, Example 7

SMILES: Cc1ccc-2c(OC(c3ccc(OCCN4CC(CF)C4)cc3)c3c-2cnc2cc(O)ccc32)c1

InChI Key: InChIKey=DRPASBVXQUEVRW-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 443440   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Estrogen receptor (Homo sapiens (Human))	BDBM443440 (US10654866, Example 7) Show SMILES Cc1ccc-2c(OC(c3ccc(OCCN4CC(CF)C4)cc3)c3c-2cnc2cc(O)ccc32)c1 Show InChI InChI=1S/C29H27FN2O3/c1-18-2-8-23-25-15-31-26-13-21(33)5-9-24(26)28(25)29(35-27(23)12-18)20-3-6-22(7-4-20)34-11-10-32-16-19(14-30)17-32/h2-9,12-13,15,19,29,33H,10-11,14,16-17H2,1H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.55	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...				US Patent US10654866 (2020)
					More data for this Ligand-Target Pair
Estrogen receptor alpha Y537S (Homo sapiens (Human))	BDBM443440 (US10654866, Example 7) Show SMILES Cc1ccc-2c(OC(c3ccc(OCCN4CC(CF)C4)cc3)c3c-2cnc2cc(O)ccc32)c1 Show InChI InChI=1S/C29H27FN2O3/c1-18-2-8-23-25-15-31-26-13-21(33)5-9-24(26)28(25)29(35-27(23)12-18)20-3-6-22(7-4-20)34-11-10-32-16-19(14-30)17-32/h2-9,12-13,15,19,29,33H,10-11,14,16-17H2,1H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	8.55	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Run the competition binding assay in a buffer containing 50 mM HEPES, pH 7.5, 1.5 mM EDTA, 150 mM NaCl, 10% glycerol, 1 mg/mL ovalbumin, and 5 mM DTT...				US Patent US10654866 (2020)
					More data for this Ligand-Target Pair