BDBM445091 (S)-4,4-difluoro-2-(4-(5-methyl-1H-pyrazol-4-yl)indoline-1-carbonyl)pyrrolidine-1-carbonitrile::US10669234, Example 30

SMILES: Cc1[nH]ncc1-c1cccc2N(CCc12)C(=O)[C@@H]1CC(F)(F)CN1C#N

InChI Key: InChIKey=XOANBZMRYZSVBZ-INIZCTEOSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 445091   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (Homo sapiens (Human))	BDBM445091 ((S)-4,4-difluoro-2-(4-(5-methyl-1H-pyrazol-4-yl)in...) Show SMILES Cc1[nH]ncc1-c1cccc2N(CCc12)C(=O)[C@@H]1CC(F)(F)CN1C#N Show InChI InChI=1S/C18H17F2N5O/c1-11-14(8-22-23-11)12-3-2-4-15-13(12)5-6-25(15)17(26)16-7-18(19,20)9-24(16)10-21/h2-4,8,16H,5-7,9H2,1H3,(H,22,23)/t16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (Homo sapiens (Human))	BDBM445091 ((S)-4,4-difluoro-2-(4-(5-methyl-1H-pyrazol-4-yl)in...) Show SMILES Cc1[nH]ncc1-c1cccc2N(CCc12)C(=O)[C@@H]1CC(F)(F)CN1C#N Show InChI InChI=1S/C18H17F2N5O/c1-11-14(8-22-23-11)12-3-2-4-15-13(12)5-6-25(15)17(26)16-7-18(19,20)9-24(16)10-21/h2-4,8,16H,5-7,9H2,1H3,(H,22,23)/t16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
MISSION THERAPEUTICS LIMITED US Patent					Assay Description Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...				US Patent US10669234 (2020)
					More data for this Ligand-Target Pair