BDBM445210 (Z)-Methyl 5-methyl-3-(((4-(N-(2-(4-methylpiperazin-1-yl)ethyl)sulfamoyl)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate, 0.8 formate::US10669235, Example 1

SMILES: COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)S(=O)(=O)NCCN3CCN(C)CC3)c3ccccc3)c2cc1C

InChI Key: InChIKey=VMNBDLPXPRVHFM-ZIADKAODSA-N

Data: 6 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 445210   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM445210 ((Z)-Methyl 5-methyl-3-(((4-(N-(2-(4-methylpiperazi...) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)S(=O)(=O)NCCN3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H35N5O5S/c1-21-19-26-27(20-25(21)31(38)41-3)34-30(37)28(26)29(22-7-5-4-6-8-22)33-23-9-11-24(12-10-23)42(39,40)32-13-14-36-17-15-35(2)16-18-36/h4-12,19-20,32-33H,13-18H2,1-3H3,(H,34,37)/b29-28-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9.93	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM445210 ((Z)-Methyl 5-methyl-3-(((4-(N-(2-(4-methylpiperazi...) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)S(=O)(=O)NCCN3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H35N5O5S/c1-21-19-26-27(20-25(21)31(38)41-3)34-30(37)28(26)29(22-7-5-4-6-8-22)33-23-9-11-24(12-10-23)42(39,40)32-13-14-36-17-15-35(2)16-18-36/h4-12,19-20,32-33H,13-18H2,1-3H3,(H,34,37)/b29-28-	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	12.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445210 ((Z)-Methyl 5-methyl-3-(((4-(N-(2-(4-methylpiperazi...) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)S(=O)(=O)NCCN3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H35N5O5S/c1-21-19-26-27(20-25(21)31(38)41-3)34-30(37)28(26)29(22-7-5-4-6-8-22)33-23-9-11-24(12-10-23)42(39,40)32-13-14-36-17-15-35(2)16-18-36/h4-12,19-20,32-33H,13-18H2,1-3H3,(H,34,37)/b29-28-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	13.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM445210 ((Z)-Methyl 5-methyl-3-(((4-(N-(2-(4-methylpiperazi...) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)S(=O)(=O)NCCN3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H35N5O5S/c1-21-19-26-27(20-25(21)31(38)41-3)34-30(37)28(26)29(22-7-5-4-6-8-22)33-23-9-11-24(12-10-23)42(39,40)32-13-14-36-17-15-35(2)16-18-36/h4-12,19-20,32-33H,13-18H2,1-3H3,(H,34,37)/b29-28-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	22.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM445210 ((Z)-Methyl 5-methyl-3-(((4-(N-(2-(4-methylpiperazi...) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)S(=O)(=O)NCCN3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H35N5O5S/c1-21-19-26-27(20-25(21)31(38)41-3)34-30(37)28(26)29(22-7-5-4-6-8-22)33-23-9-11-24(12-10-23)42(39,40)32-13-14-36-17-15-35(2)16-18-36/h4-12,19-20,32-33H,13-18H2,1-3H3,(H,34,37)/b29-28-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	35	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR1 (FGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR1 prote...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM445210 ((Z)-Methyl 5-methyl-3-(((4-(N-(2-(4-methylpiperazi...) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)S(=O)(=O)NCCN3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H35N5O5S/c1-21-19-26-27(20-25(21)31(38)41-3)34-30(37)28(26)29(22-7-5-4-6-8-22)33-23-9-11-24(12-10-23)42(39,40)32-13-14-36-17-15-35(2)16-18-36/h4-12,19-20,32-33H,13-18H2,1-3H3,(H,34,37)/b29-28-	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	97.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against VEGFR1 (VEGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR1 pr...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair