Found 12 hits for monomerid = 445214 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM445214
(US10669235, Example 5 | US11208381, Example 5)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C33H37N5O4/c1-22-20-27-28(21-26(22)33(41)42-3)36-32(40)29(27)30(23-8-5-4-6-9-23)35-25-12-10-24(11-13-25)31(39)34-14-17-38-16-7-15-37(2)18-19-38/h4-6,8-13,20-21,35H,7,14-19H2,1-3H3,(H,34,39)(H,36,40)/b30-29- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 10.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM445214
(US10669235, Example 5 | US11208381, Example 5)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C33H37N5O4/c1-22-20-27-28(21-26(22)33(41)42-3)36-32(40)29(27)30(23-8-5-4-6-9-23)35-25-12-10-24(11-13-25)31(39)34-14-17-38-16-7-15-37(2)18-19-38/h4-6,8-13,20-21,35H,7,14-19H2,1-3H3,(H,34,39)(H,36,40)/b30-29- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 10.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM445214
(US10669235, Example 5 | US11208381, Example 5)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C33H37N5O4/c1-22-20-27-28(21-26(22)33(41)42-3)36-32(40)29(27)30(23-8-5-4-6-9-23)35-25-12-10-24(11-13-25)31(39)34-14-17-38-16-7-15-37(2)18-19-38/h4-6,8-13,20-21,35H,7,14-19H2,1-3H3,(H,34,39)(H,36,40)/b30-29- | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 12.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM445214
(US10669235, Example 5 | US11208381, Example 5)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C33H37N5O4/c1-22-20-27-28(21-26(22)33(41)42-3)36-32(40)29(27)30(23-8-5-4-6-9-23)35-25-12-10-24(11-13-25)31(39)34-14-17-38-16-7-15-37(2)18-19-38/h4-6,8-13,20-21,35H,7,14-19H2,1-3H3,(H,34,39)(H,36,40)/b30-29- | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 12.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM445214
(US10669235, Example 5 | US11208381, Example 5)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C33H37N5O4/c1-22-20-27-28(21-26(22)33(41)42-3)36-32(40)29(27)30(23-8-5-4-6-9-23)35-25-12-10-24(11-13-25)31(39)34-14-17-38-16-7-15-37(2)18-19-38/h4-6,8-13,20-21,35H,7,14-19H2,1-3H3,(H,34,39)(H,36,40)/b30-29- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 12.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
VHL/PDGFRB
(Homo sapiens (Human)) | BDBM445214
(US10669235, Example 5 | US11208381, Example 5)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C33H37N5O4/c1-22-20-27-28(21-26(22)33(41)42-3)36-32(40)29(27)30(23-8-5-4-6-9-23)35-25-12-10-24(11-13-25)31(39)34-14-17-38-16-7-15-37(2)18-19-38/h4-6,8-13,20-21,35H,7,14-19H2,1-3H3,(H,34,39)(H,36,40)/b30-29- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 12.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM445214
(US10669235, Example 5 | US11208381, Example 5)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C33H37N5O4/c1-22-20-27-28(21-26(22)33(41)42-3)36-32(40)29(27)30(23-8-5-4-6-9-23)35-25-12-10-24(11-13-25)31(39)34-14-17-38-16-7-15-37(2)18-19-38/h4-6,8-13,20-21,35H,7,14-19H2,1-3H3,(H,34,39)(H,36,40)/b30-29- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM445214
(US10669235, Example 5 | US11208381, Example 5)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C33H37N5O4/c1-22-20-27-28(21-26(22)33(41)42-3)36-32(40)29(27)30(23-8-5-4-6-9-23)35-25-12-10-24(11-13-25)31(39)34-14-17-38-16-7-15-37(2)18-19-38/h4-6,8-13,20-21,35H,7,14-19H2,1-3H3,(H,34,39)(H,36,40)/b30-29- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM445214
(US10669235, Example 5 | US11208381, Example 5)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C33H37N5O4/c1-22-20-27-28(21-26(22)33(41)42-3)36-32(40)29(27)30(23-8-5-4-6-9-23)35-25-12-10-24(11-13-25)31(39)34-14-17-38-16-7-15-37(2)18-19-38/h4-6,8-13,20-21,35H,7,14-19H2,1-3H3,(H,34,39)(H,36,40)/b30-29- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 43.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against FGFR1 (FGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR1 prote... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM445214
(US10669235, Example 5 | US11208381, Example 5)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C33H37N5O4/c1-22-20-27-28(21-26(22)33(41)42-3)36-32(40)29(27)30(23-8-5-4-6-9-23)35-25-12-10-24(11-13-25)31(39)34-14-17-38-16-7-15-37(2)18-19-38/h4-6,8-13,20-21,35H,7,14-19H2,1-3H3,(H,34,39)(H,36,40)/b30-29- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 43.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM445214
(US10669235, Example 5 | US11208381, Example 5)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C33H37N5O4/c1-22-20-27-28(21-26(22)33(41)42-3)36-32(40)29(27)30(23-8-5-4-6-9-23)35-25-12-10-24(11-13-25)31(39)34-14-17-38-16-7-15-37(2)18-19-38/h4-6,8-13,20-21,35H,7,14-19H2,1-3H3,(H,34,39)(H,36,40)/b30-29- | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 72.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against VEGFR1 (VEGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR1 pr... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1 and 2 (Flt-1 and KDR)
(Homo sapiens (Human)) | BDBM445214
(US10669235, Example 5 | US11208381, Example 5)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C33H37N5O4/c1-22-20-27-28(21-26(22)33(41)42-3)36-32(40)29(27)30(23-8-5-4-6-9-23)35-25-12-10-24(11-13-25)31(39)34-14-17-38-16-7-15-37(2)18-19-38/h4-6,8-13,20-21,35H,7,14-19H2,1-3H3,(H,34,39)(H,36,40)/b30-29- | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 72.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |