BDBM445248 US10669235, Example 39

SMILES: COCCNC(=O)CN1CCN(CC1)C(=O)c1ccc(N\C(=C2/C(=O)Nc3cc(C(=O)OC)c(C)cc23)c2ccccc2)cc1

InChI Key: InChIKey=OLBVLPUBUBRBGW-KTMFPKCZSA-N

Data: 6 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 445248   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM445248 (US10669235, Example 39) Show SMILES COCCNC(=O)CN1CCN(CC1)C(=O)c1ccc(N\C(=C2/C(=O)Nc3cc(C(=O)OC)c(C)cc23)c2ccccc2)cc1 Show InChI InChI=1S/C34H37N5O6/c1-22-19-27-28(20-26(22)34(43)45-3)37-32(41)30(27)31(23-7-5-4-6-8-23)36-25-11-9-24(10-12-25)33(42)39-16-14-38(15-17-39)21-29(40)35-13-18-44-2/h4-12,19-20,36H,13-18,21H2,1-3H3,(H,35,40)(H,37,41)/b31-30-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	14.1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445248 (US10669235, Example 39) Show SMILES COCCNC(=O)CN1CCN(CC1)C(=O)c1ccc(N\C(=C2/C(=O)Nc3cc(C(=O)OC)c(C)cc23)c2ccccc2)cc1 Show InChI InChI=1S/C34H37N5O6/c1-22-19-27-28(20-26(22)34(43)45-3)37-32(41)30(27)31(23-7-5-4-6-8-23)36-25-11-9-24(10-12-25)33(42)39-16-14-38(15-17-39)21-29(40)35-13-18-44-2/h4-12,19-20,36H,13-18,21H2,1-3H3,(H,35,40)(H,37,41)/b31-30-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	14.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM445248 (US10669235, Example 39) Show SMILES COCCNC(=O)CN1CCN(CC1)C(=O)c1ccc(N\C(=C2/C(=O)Nc3cc(C(=O)OC)c(C)cc23)c2ccccc2)cc1 Show InChI InChI=1S/C34H37N5O6/c1-22-19-27-28(20-26(22)34(43)45-3)37-32(41)30(27)31(23-7-5-4-6-8-23)36-25-11-9-24(10-12-25)33(42)39-16-14-38(15-17-39)21-29(40)35-13-18-44-2/h4-12,19-20,36H,13-18,21H2,1-3H3,(H,35,40)(H,37,41)/b31-30-	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	15.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM445248 (US10669235, Example 39) Show SMILES COCCNC(=O)CN1CCN(CC1)C(=O)c1ccc(N\C(=C2/C(=O)Nc3cc(C(=O)OC)c(C)cc23)c2ccccc2)cc1 Show InChI InChI=1S/C34H37N5O6/c1-22-19-27-28(20-26(22)34(43)45-3)37-32(41)30(27)31(23-7-5-4-6-8-23)36-25-11-9-24(10-12-25)33(42)39-16-14-38(15-17-39)21-29(40)35-13-18-44-2/h4-12,19-20,36H,13-18,21H2,1-3H3,(H,35,40)(H,37,41)/b31-30-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	31.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM445248 (US10669235, Example 39) Show SMILES COCCNC(=O)CN1CCN(CC1)C(=O)c1ccc(N\C(=C2/C(=O)Nc3cc(C(=O)OC)c(C)cc23)c2ccccc2)cc1 Show InChI InChI=1S/C34H37N5O6/c1-22-19-27-28(20-26(22)34(43)45-3)37-32(41)30(27)31(23-7-5-4-6-8-23)36-25-11-9-24(10-12-25)33(42)39-16-14-38(15-17-39)21-29(40)35-13-18-44-2/h4-12,19-20,36H,13-18,21H2,1-3H3,(H,35,40)(H,37,41)/b31-30-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	47.4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR1 (FGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR1 prote...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM445248 (US10669235, Example 39) Show SMILES COCCNC(=O)CN1CCN(CC1)C(=O)c1ccc(N\C(=C2/C(=O)Nc3cc(C(=O)OC)c(C)cc23)c2ccccc2)cc1 Show InChI InChI=1S/C34H37N5O6/c1-22-19-27-28(20-26(22)34(43)45-3)37-32(41)30(27)31(23-7-5-4-6-8-23)36-25-11-9-24(10-12-25)33(42)39-16-14-38(15-17-39)21-29(40)35-13-18-44-2/h4-12,19-20,36H,13-18,21H2,1-3H3,(H,35,40)(H,37,41)/b31-30-	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	133	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against VEGFR1 (VEGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR1 pr...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair