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SMILES: COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCC4(CC3)N(C)CCCNC4=O)c3ccccc3)c2cc1C

InChI Key: InChIKey=URKLHKCMUZBPEN-FLWNBWAVSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 445252   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM445252 (US10669235, Example 43 | US11208381, Example 43) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCC4(CC3)N(C)CCCNC4=O)c3ccccc3)c2cc1C Show InChI InChI=1S/C35H37N5O5/c1-22-20-27-28(21-26(22)33(43)45-3)38-31(41)29(27)30(23-8-5-4-6-9-23)37-25-12-10-24(11-13-25)32(42)40-18-14-35(15-19-40)34(44)36-16-7-17-39(35)2/h4-6,8-13,20-21,37H,7,14-19H2,1-3H3,(H,36,44)(H,38,41)/b30-29-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	11.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM445252 (US10669235, Example 43 | US11208381, Example 43) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCC4(CC3)N(C)CCCNC4=O)c3ccccc3)c2cc1C Show InChI InChI=1S/C35H37N5O5/c1-22-20-27-28(21-26(22)33(43)45-3)38-31(41)29(27)30(23-8-5-4-6-9-23)37-25-12-10-24(11-13-25)32(42)40-18-14-35(15-19-40)34(44)36-16-7-17-39(35)2/h4-6,8-13,20-21,37H,7,14-19H2,1-3H3,(H,36,44)(H,38,41)/b30-29-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		11.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445252 (US10669235, Example 43 | US11208381, Example 43) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCC4(CC3)N(C)CCCNC4=O)c3ccccc3)c2cc1C Show InChI InChI=1S/C35H37N5O5/c1-22-20-27-28(21-26(22)33(43)45-3)38-31(41)29(27)30(23-8-5-4-6-9-23)37-25-12-10-24(11-13-25)32(42)40-18-14-35(15-19-40)34(44)36-16-7-17-39(35)2/h4-6,8-13,20-21,37H,7,14-19H2,1-3H3,(H,36,44)(H,38,41)/b30-29-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	20.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445252 (US10669235, Example 43 | US11208381, Example 43) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCC4(CC3)N(C)CCCNC4=O)c3ccccc3)c2cc1C Show InChI InChI=1S/C35H37N5O5/c1-22-20-27-28(21-26(22)33(43)45-3)38-31(41)29(27)30(23-8-5-4-6-9-23)37-25-12-10-24(11-13-25)32(42)40-18-14-35(15-19-40)34(44)36-16-7-17-39(35)2/h4-6,8-13,20-21,37H,7,14-19H2,1-3H3,(H,36,44)(H,38,41)/b30-29-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		20.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM445252 (US10669235, Example 43 | US11208381, Example 43) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCC4(CC3)N(C)CCCNC4=O)c3ccccc3)c2cc1C Show InChI InChI=1S/C35H37N5O5/c1-22-20-27-28(21-26(22)33(43)45-3)38-31(41)29(27)30(23-8-5-4-6-9-23)37-25-12-10-24(11-13-25)32(42)40-18-14-35(15-19-40)34(44)36-16-7-17-39(35)2/h4-6,8-13,20-21,37H,7,14-19H2,1-3H3,(H,36,44)(H,38,41)/b30-29-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	25.2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM445252 (US10669235, Example 43 | US11208381, Example 43) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCC4(CC3)N(C)CCCNC4=O)c3ccccc3)c2cc1C Show InChI InChI=1S/C35H37N5O5/c1-22-20-27-28(21-26(22)33(43)45-3)38-31(41)29(27)30(23-8-5-4-6-9-23)37-25-12-10-24(11-13-25)32(42)40-18-14-35(15-19-40)34(44)36-16-7-17-39(35)2/h4-6,8-13,20-21,37H,7,14-19H2,1-3H3,(H,36,44)(H,38,41)/b30-29-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		25.2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM445252 (US10669235, Example 43 | US11208381, Example 43) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCC4(CC3)N(C)CCCNC4=O)c3ccccc3)c2cc1C Show InChI InChI=1S/C35H37N5O5/c1-22-20-27-28(21-26(22)33(43)45-3)38-31(41)29(27)30(23-8-5-4-6-9-23)37-25-12-10-24(11-13-25)32(42)40-18-14-35(15-19-40)34(44)36-16-7-17-39(35)2/h4-6,8-13,20-21,37H,7,14-19H2,1-3H3,(H,36,44)(H,38,41)/b30-29-	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	30.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM445252 (US10669235, Example 43 | US11208381, Example 43) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCC4(CC3)N(C)CCCNC4=O)c3ccccc3)c2cc1C Show InChI InChI=1S/C35H37N5O5/c1-22-20-27-28(21-26(22)33(43)45-3)38-31(41)29(27)30(23-8-5-4-6-9-23)37-25-12-10-24(11-13-25)32(42)40-18-14-35(15-19-40)34(44)36-16-7-17-39(35)2/h4-6,8-13,20-21,37H,7,14-19H2,1-3H3,(H,36,44)(H,38,41)/b30-29-	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		30.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM445252 (US10669235, Example 43 | US11208381, Example 43) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCC4(CC3)N(C)CCCNC4=O)c3ccccc3)c2cc1C Show InChI InChI=1S/C35H37N5O5/c1-22-20-27-28(21-26(22)33(43)45-3)38-31(41)29(27)30(23-8-5-4-6-9-23)37-25-12-10-24(11-13-25)32(42)40-18-14-35(15-19-40)34(44)36-16-7-17-39(35)2/h4-6,8-13,20-21,37H,7,14-19H2,1-3H3,(H,36,44)(H,38,41)/b30-29-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	66.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against VEGFR1 (VEGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR1 pr...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM445252 (US10669235, Example 43 | US11208381, Example 43) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCC4(CC3)N(C)CCCNC4=O)c3ccccc3)c2cc1C Show InChI InChI=1S/C35H37N5O5/c1-22-20-27-28(21-26(22)33(43)45-3)38-31(41)29(27)30(23-8-5-4-6-9-23)37-25-12-10-24(11-13-25)32(42)40-18-14-35(15-19-40)34(44)36-16-7-17-39(35)2/h4-6,8-13,20-21,37H,7,14-19H2,1-3H3,(H,36,44)(H,38,41)/b30-29-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		66.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM445252 (US10669235, Example 43 | US11208381, Example 43) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCC4(CC3)N(C)CCCNC4=O)c3ccccc3)c2cc1C Show InChI InChI=1S/C35H37N5O5/c1-22-20-27-28(21-26(22)33(43)45-3)38-31(41)29(27)30(23-8-5-4-6-9-23)37-25-12-10-24(11-13-25)32(42)40-18-14-35(15-19-40)34(44)36-16-7-17-39(35)2/h4-6,8-13,20-21,37H,7,14-19H2,1-3H3,(H,36,44)(H,38,41)/b30-29-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	112	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR1 (FGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR1 prote...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM445252 (US10669235, Example 43 | US11208381, Example 43) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCC4(CC3)N(C)CCCNC4=O)c3ccccc3)c2cc1C Show InChI InChI=1S/C35H37N5O5/c1-22-20-27-28(21-26(22)33(43)45-3)38-31(41)29(27)30(23-8-5-4-6-9-23)37-25-12-10-24(11-13-25)32(42)40-18-14-35(15-19-40)34(44)36-16-7-17-39(35)2/h4-6,8-13,20-21,37H,7,14-19H2,1-3H3,(H,36,44)(H,38,41)/b30-29-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		112	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair