BDBM445261 US10669235, Example 52

SMILES: COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCS(=O)(=O)CC3)c3ccccc3)c2cc1C

InChI Key: InChIKey=LCSINNGGVIROLG-DQSJHHFOSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 445261   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445261 (US10669235, Example 52) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCS(=O)(=O)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H32N4O6S/c1-20-18-25-26(19-24(20)31(38)41-2)34-30(37)27(25)28(21-6-4-3-5-7-21)33-23-10-8-22(9-11-23)29(36)32-12-13-35-14-16-42(39,40)17-15-35/h3-11,18-19,33H,12-17H2,1-2H3,(H,32,36)(H,34,37)/b28-27-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	19.2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM445261 (US10669235, Example 52) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCS(=O)(=O)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H32N4O6S/c1-20-18-25-26(19-24(20)31(38)41-2)34-30(37)27(25)28(21-6-4-3-5-7-21)33-23-10-8-22(9-11-23)29(36)32-12-13-35-14-16-42(39,40)17-15-35/h3-11,18-19,33H,12-17H2,1-2H3,(H,32,36)(H,34,37)/b28-27-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	30.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM445261 (US10669235, Example 52) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCS(=O)(=O)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H32N4O6S/c1-20-18-25-26(19-24(20)31(38)41-2)34-30(37)27(25)28(21-6-4-3-5-7-21)33-23-10-8-22(9-11-23)29(36)32-12-13-35-14-16-42(39,40)17-15-35/h3-11,18-19,33H,12-17H2,1-2H3,(H,32,36)(H,34,37)/b28-27-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	50.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR1 (FGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR1 prote...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM445261 (US10669235, Example 52) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCS(=O)(=O)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H32N4O6S/c1-20-18-25-26(19-24(20)31(38)41-2)34-30(37)27(25)28(21-6-4-3-5-7-21)33-23-10-8-22(9-11-23)29(36)32-12-13-35-14-16-42(39,40)17-15-35/h3-11,18-19,33H,12-17H2,1-2H3,(H,32,36)(H,34,37)/b28-27-	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	251	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against VEGFR1 (VEGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR1 pr...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair