BDBM4454 4-(3-Dimethylaminophenylamino)-6,7-dimethoxyquinoline-3-carbonitrile::4-{[3-(dimethylamino)phenyl]amino}-6,7-dimethoxyquinoline-3-carbonitrile::6,7-dialkoxyquinoline-3-carbonitrile deriv. 17
SMILES: COc1cc2ncc(C#N)c(Nc3cccc(c3)N(C)C)c2cc1OC
InChI Key: InChIKey=OLPCFXOXZCAXNQ-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM4454![]() (4-(3-Dimethylaminophenylamino)-6,7-dimethoxyquinol...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 851 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Institute of Science and Technology Curated by ChEMBL | Assay Description Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISA | Eur J Med Chem 43: 781-91 (2008) Article DOI: 10.1016/j.ejmech.2007.06.006 BindingDB Entry DOI: 10.7270/Q2DJ5GXN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM4454![]() (4-(3-Dimethylaminophenylamino)-6,7-dimethoxyquinol...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 850 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Wyeth-Ayerst Research | Assay Description The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po... | J Med Chem 43: 3244-56 (2000) Article DOI: 10.1021/jm000206a BindingDB Entry DOI: 10.7270/Q22V2D9M | |||||||||||
More data for this Ligand-Target Pair |