null

SMILES: C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cccc(NC(=O)c2ccc(Cl)cn2)n1

InChI Key: InChIKey=CKRKVUFHQBIJHR-DLBZAZTESA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 445495   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 2 (Homo sapiens (Human))	BDBM445495 (US10683287, Example 21) Show SMILES C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cccc(NC(=O)c2ccc(Cl)cn2)n1 |r,c:7| Show InChI InChI=1S/C18H17ClF3N5O2/c1-16(9-29-17(2,15(23)27-16)18(20,21)22)12-4-3-5-13(25-12)26-14(28)11-7-6-10(19)8-24-11/h3-8H,9H2,1-2H3,(H2,23,27)(H,25,26,28)/t16-,17+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...				US Patent US10683287 (2020) BindingDB Entry DOI: 10.7270/Q2DZ0CCG
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM445495 (US10683287, Example 21) Show SMILES C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cccc(NC(=O)c2ccc(Cl)cn2)n1 |r,c:7| Show InChI InChI=1S/C18H17ClF3N5O2/c1-16(9-29-17(2,15(23)27-16)18(20,21)22)12-4-3-5-13(25-12)26-14(28)11-7-6-10(19)8-24-11/h3-8H,9H2,1-2H3,(H2,23,27)(H,25,26,28)/t16-,17+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...				US Patent US10683287 (2020) BindingDB Entry DOI: 10.7270/Q2DZ0CCG
					More data for this Ligand-Target Pair