null

SMILES: CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccc(F)cc3)c2c(=O)[nH]c1=O

InChI Key: InChIKey=SMDQFUGCZCQACS-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 445690   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tryptophan 5-hydroxylase 1 (Homo sapiens (Human))	BDBM445690 (Ex. 26/KM-06-114/(I-26) | US10683309, Example 26 |...) Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccc(F)cc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C21H19FN6O2S/c1-3-27-18-17(19(29)25-20(27)30)28(10-13-4-6-14(22)7-5-13)16(24-18)8-15-11-26-9-12(2)31-21(26)23-15/h4-7,9,11H,3,8,10H2,1-2H3,(H,25,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	217	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US10683309 (2020)
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445690 (Ex. 26/KM-06-114/(I-26) | US10683309, Example 26 |...) Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccc(F)cc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C21H19FN6O2S/c1-3-27-18-17(19(29)25-20(27)30)28(10-13-4-6-14(22)7-5-13)16(24-18)8-15-11-26-9-12(2)31-21(26)23-15/h4-7,9,11H,3,8,10H2,1-2H3,(H,25,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US11028104 (2021)
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 1 (Homo sapiens (Human))	BDBM445690 (Ex. 26/KM-06-114/(I-26) | US10683309, Example 26 |...) Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccc(F)cc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C21H19FN6O2S/c1-3-27-18-17(19(29)25-20(27)30)28(10-13-4-6-14(22)7-5-13)16(24-18)8-15-11-26-9-12(2)31-21(26)23-15/h4-7,9,11H,3,8,10H2,1-2H3,(H,25,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	217	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US11028104 (2021)
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445690 (Ex. 26/KM-06-114/(I-26) | US10683309, Example 26 |...) Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccc(F)cc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C21H19FN6O2S/c1-3-27-18-17(19(29)25-20(27)30)28(10-13-4-6-14(22)7-5-13)16(24-18)8-15-11-26-9-12(2)31-21(26)23-15/h4-7,9,11H,3,8,10H2,1-2H3,(H,25,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US10683309 (2020)
					More data for this Ligand-Target Pair