null

SMILES: CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccc(OC)cc3)c2c(=O)[nH]c1=O

InChI Key: InChIKey=CHNXRVLXFOXYEC-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 445691   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tryptophan 5-hydroxylase 1 (Homo sapiens (Human))	BDBM445691 (Ex. 27/KM-06-115/(I-27) | US10683309, Example 27 |...) Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccc(OC)cc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C22H22N6O3S/c1-4-27-19-18(20(29)25-21(27)30)28(11-14-5-7-16(31-3)8-6-14)17(24-19)9-15-12-26-10-13(2)32-22(26)23-15/h5-8,10,12H,4,9,11H2,1-3H3,(H,25,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	133	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US10683309 (2020)
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445691 (Ex. 27/KM-06-115/(I-27) | US10683309, Example 27 |...) Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccc(OC)cc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C22H22N6O3S/c1-4-27-19-18(20(29)25-21(27)30)28(11-14-5-7-16(31-3)8-6-14)17(24-19)9-15-12-26-10-13(2)32-22(26)23-15/h5-8,10,12H,4,9,11H2,1-3H3,(H,25,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US11028104 (2021)
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 1 (Homo sapiens (Human))	BDBM445691 (Ex. 27/KM-06-115/(I-27) | US10683309, Example 27 |...) Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccc(OC)cc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C22H22N6O3S/c1-4-27-19-18(20(29)25-21(27)30)28(11-14-5-7-16(31-3)8-6-14)17(24-19)9-15-12-26-10-13(2)32-22(26)23-15/h5-8,10,12H,4,9,11H2,1-3H3,(H,25,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	133	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US11028104 (2021)
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445691 (Ex. 27/KM-06-115/(I-27) | US10683309, Example 27 |...) Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccc(OC)cc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C22H22N6O3S/c1-4-27-19-18(20(29)25-21(27)30)28(11-14-5-7-16(31-3)8-6-14)17(24-19)9-15-12-26-10-13(2)32-22(26)23-15/h5-8,10,12H,4,9,11H2,1-3H3,(H,25,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US10683309 (2020)
					More data for this Ligand-Target Pair