BDBM4465 6,7-Dimethoxy-4-(3-methylthiophenylamino)quinoline-3-carbonitrile Hydrochloride::6,7-dialkoxyquinoline-3-carbonitrile deriv. 28::6,7-dimethoxy-4-{[3-(methylsulfanyl)phenyl]amino}quinoline-3-carbonitrile

SMILES: COc1cc2ncc(C#N)c(Nc3cccc(SC)c3)c2cc1OC

InChI Key: InChIKey=ZSJDOQUXSFYFRM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 4465   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM4465 (6,7-Dimethoxy-4-(3-methylthiophenylamino)quinoline...) Show SMILES COc1cc2ncc(C#N)c(Nc3cccc(SC)c3)c2cc1OC Show InChI InChI=1S/C19H17N3O2S/c1-23-17-8-15-16(9-18(17)24-2)21-11-12(10-20)19(15)22-13-5-4-6-14(7-13)25-3/h4-9,11H,1-3H3,(H,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	759	n/a	n/a	n/a	n/a	n/a	n/a
Korea Institute of Science and Technology Curated by ChEMBL					Assay Description Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISA				Eur J Med Chem 43: 781-91 (2008) Article DOI: 10.1016/j.ejmech.2007.06.006 BindingDB Entry DOI: 10.7270/Q2DJ5GXN
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM4465 (6,7-Dimethoxy-4-(3-methylthiophenylamino)quinoline...) Show SMILES COc1cc2ncc(C#N)c(Nc3cccc(SC)c3)c2cc1OC Show InChI InChI=1S/C19H17N3O2S/c1-23-17-8-15-16(9-18(17)24-2)21-11-12(10-20)19(15)22-13-5-4-6-14(7-13)25-3/h4-9,11H,1-3H3,(H,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	760	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research					Assay Description The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...				J Med Chem 43: 3244-56 (2000) Article DOI: 10.1021/jm000206a BindingDB Entry DOI: 10.7270/Q22V2D9M
					More data for this Ligand-Target Pair