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SMILES: COCC(COC)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1-c1ccccn1

InChI Key: InChIKey=YRFAUVOAMIJGGC-GUYCJALGSA-N

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 447695   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Apelin receptor


(Homo sapiens (Human))		BDBM447695
PNG
(US10689367, Example 14.0)
Show SMILES COCC(COC)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1-c1ccccn1 |r|
Show InChI InChI=1S/C20H26ClN7O5S/c1-13(17(33-4)18-23-9-14(21)10-24-18)34(29,30)27-20-26-25-19(16-7-5-6-8-22-16)28(20)15(11-31-2)12-32-3/h5-10,13,15,17H,11-12H2,1-4H3,(H,26,27)/t13-,17-/m0/s1
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PC cid
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US Patent
n/an/an/an/a 6.40n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10689367 (2020)


BindingDB Entry DOI: 10.7270/Q2P84FXK
More data for this
Ligand-Target Pair