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SMILES: CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1CCC(N)=O)c1ncc(Cl)cn1

InChI Key: InChIKey=KWDUAZGSIFRBHM-ZBEGNZNMSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 447715   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Apelin receptor


(Homo sapiens (Human))		BDBM447715
PNG
(US10689367, Example 45.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1CCC(N)=O)c1ncc(Cl)cn1 |r|
Show InChI InChI=1S/C19H23ClN8O5S/c1-11(16(33-3)17-22-9-12(20)10-23-17)34(30,31)27-19-26-25-18(28(19)8-7-14(21)29)13-5-4-6-15(24-13)32-2/h4-6,9-11,16H,7-8H2,1-3H3,(H2,21,29)(H,26,27)/t11-,16-/m0/s1
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US Patent
n/an/an/an/a 60n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10689367 (2020)


BindingDB Entry DOI: 10.7270/Q2P84FXK
More data for this
Ligand-Target Pair