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SMILES: CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1CCS(C)(=O)=O)c1ncc(Cl)cn1

InChI Key: InChIKey=HVOKXLJQHYYQJV-LRDDRELGSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 447738   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Apelin receptor


(Homo sapiens (Human))		BDBM447738
PNG
(US10689367, Example 57.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1CCS(C)(=O)=O)c1ncc(Cl)cn1 |r|
Show InChI InChI=1S/C19H24ClN7O6S2/c1-12(16(33-3)17-21-10-13(20)11-22-17)35(30,31)26-19-25-24-18(27(19)8-9-34(4,28)29)14-6-5-7-15(23-14)32-2/h5-7,10-12,16H,8-9H2,1-4H3,(H,25,26)/t12-,16-/m0/s1
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US Patent
n/an/an/an/a 211n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10689367 (2020)


BindingDB Entry DOI: 10.7270/Q2P84FXK
More data for this
Ligand-Target Pair