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SMILES: COCC1(CC1)n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1-c1cccc(OC)n1

InChI Key: InChIKey=VXLINPFQTSOKPC-FXAWDEMLSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 447745   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Apelin receptor


(Homo sapiens (Human))		BDBM447745
PNG
(US10689367, Example 64.0)
Show SMILES COCC1(CC1)n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1-c1cccc(OC)n1 |r|
Show InChI InChI=1S/C24H33N7O5S/c1-15(2)36-20(21-25-12-16(3)13-26-21)17(4)37(32,33)30-23-29-28-22(18-8-7-9-19(27-18)35-6)31(23)24(10-11-24)14-34-5/h7-9,12-13,15,17,20H,10-11,14H2,1-6H3,(H,29,30)/t17-,20+/m0/s1
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PC cid
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US Patent
n/an/an/an/a 0.160n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...

US Patent US10689367 (2020)


BindingDB Entry DOI: 10.7270/Q2P84FXK
More data for this
Ligand-Target Pair