BDBM448014 US10689367, Example 342.0::US10689367, Example 343.0

SMILES: CC[C@H](c1cc(F)cc(F)c1)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1-c1cccc(OC)n1

InChI Key: InChIKey=FJYDFUZXLFKLQK-OTPBECDQSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 448014   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apelin receptor (Homo sapiens (Human))	BDBM448014 (US10689367, Example 342.0 | US10689367, Example 34...) Show SMILES CC[C@H](c1cc(F)cc(F)c1)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1-c1cccc(OC)n1 |r| Show InChI InChI=1S/C25H26ClF2N7O4S/c1-5-20(15-9-17(27)11-18(28)10-15)35-24(19-7-6-8-21(31-19)38-3)32-33-25(35)34-40(36,37)14(2)22(39-4)23-29-12-16(26)13-30-23/h6-14,20,22H,5H2,1-4H3,(H,33,34)/t14-,20+,22-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.100	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...				US Patent US10689367 (2020)
					More data for this Ligand-Target Pair
Apelin receptor (Homo sapiens (Human))	BDBM448014 (US10689367, Example 342.0 | US10689367, Example 34...) Show SMILES CC[C@H](c1cc(F)cc(F)c1)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1-c1cccc(OC)n1 |r| Show InChI InChI=1S/C25H26ClF2N7O4S/c1-5-20(15-9-17(27)11-18(28)10-15)35-24(19-7-6-8-21(31-19)38-3)32-33-25(35)34-40(36,37)14(2)22(39-4)23-29-12-16(26)13-30-23/h6-14,20,22H,5H2,1-4H3,(H,33,34)/t14-,20+,22-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.0500	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...				US Patent US10689367 (2020)
					More data for this Ligand-Target Pair