BindingDB logo
myBDB logout

null

SMILES: COc1nc(C)c2nc(-c3cncc(F)c3)n(Cc3ccc(O[C@H]4CCN(C)C4)cc3F)c2n1

InChI Key: InChIKey=QDOZSVYNQAOLSQ-IBGZPJMESA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 450210   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Toll-like receptor 7


(Homo sapiens (Human))		BDBM450210
PNG
(US10703755, Example 414)
Show SMILES COc1nc(C)c2nc(-c3cncc(F)c3)n(Cc3ccc(O[C@H]4CCN(C)C4)cc3F)c2n1 |r|
Show InChI InChI=1S/C24H24F2N6O2/c1-14-21-23(30-24(28-14)33-3)32(22(29-21)16-8-17(25)11-27-10-16)12-15-4-5-18(9-20(15)26)34-19-6-7-31(2)13-19/h4-5,8-11,19H,6-7,12-13H2,1-3H3/t19-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 16n/an/an/an/an/an/a



SUMITOMO DAINIPPON PHARMA CO., LTD.

US Patent


Assay Description
As human TLR7 expressing cell line, HEK293 cell line was bought from IMGENEX Corporation (TLR7/NF-ηB/SEAPorter™ HEK293 cell), which is human emb...

US Patent US10703755 (2020)

More data for this
Ligand-Target Pair