null
SMILES: COC(=O)c1ccsc1NC(=O)c1cccc(C[n+]2cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c3nc(N)nc([O-])c23)c1
InChI Key: InChIKey=SQUOJOUYLPOCFN-GTQCGCAASA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451153 (US10676499, Example 42) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 4.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c... | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Eukaryotic translation initiation factor 4E (Homo sapiens (Human)) | BDBM451153 (US10676499, Example 42) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis. | US Patent US10676499 (2020) BindingDB Entry DOI: 10.7270/Q2K64N44 | |||||||||||
More data for this Ligand-Target Pair |