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SMILES: CN([C@@H]1C[C@@H]([C@H](O)c2ccc(F)c(F)c2)[C@@H](O)[C@H]1O)c1ncnc(C)n1

InChI Key: InChIKey=JDWALYZUTVLXTP-SHSWAGTRSA-N

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 451220   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))		BDBM451220
PNG
(US10709709, Example 47)
Show SMILES CN([C@@H]1C[C@@H]([C@H](O)c2ccc(F)c(F)c2)[C@@H](O)[C@H]1O)c1ncnc(C)n1 |r|
Show InChI InChI=1S/C17H20F2N4O3/c1-8-20-7-21-17(22-8)23(2)13-6-10(15(25)16(13)26)14(24)9-3-4-11(18)12(19)5-9/h3-5,7,10,13-16,24-26H,6H2,1-2H3/t10-,13+,14+,15+,16-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.95E+4n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...

US Patent US10709709 (2020)


BindingDB Entry DOI: 10.7270/Q26113CC
More data for this
Ligand-Target Pair