Found 14 hits for monomerid = 451791 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451791
(US10710980, Example 23 | US10947218, Example 23)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(CN2CC3(CCC3)C2)cc1 |r,wU:10.10,wD:13.14,(-4.25,3.17,;-2.92,2.4,;-1.59,3.17,;-.25,2.4,;-.25,.86,;-1.59,.09,;-2.92,.86,;-4.25,.09,;-4.25,-1.45,;-5.59,.86,;-6.92,.09,;-6.52,-1.39,;-7.61,-2.48,;-9.1,-2.08,;-10.19,-3.17,;-9.5,-.6,;-8.41,.49,;1.08,.09,;1.08,-1.45,;2.41,-2.22,;3.75,-1.45,;5.08,-2.22,;6.42,-1.45,;7.9,-1.85,;8.3,-.36,;9.79,-.76,;10.19,.73,;8.7,1.13,;6.81,.04,;3.75,.09,;2.41,.86,)| Show InChI InChI=1S/C25H32N4O2/c26-23-22(24(31)28-20-6-8-21(30)9-7-20)12-19(13-27-23)18-4-2-17(3-5-18)14-29-15-25(16-29)10-1-11-25/h2-5,12-13,20-21,30H,1,6-11,14-16H2,(H2,26,27)(H,28,31)/t20-,21- | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ... |
US Patent US10710980 (2020)
|
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein receptor type-1A [198-525]
(Homo sapiens (Human)) | BDBM451791
(US10710980, Example 23 | US10947218, Example 23)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(CN2CC3(CCC3)C2)cc1 |r,wU:10.10,wD:13.14,(-4.25,3.17,;-2.92,2.4,;-1.59,3.17,;-.25,2.4,;-.25,.86,;-1.59,.09,;-2.92,.86,;-4.25,.09,;-4.25,-1.45,;-5.59,.86,;-6.92,.09,;-6.52,-1.39,;-7.61,-2.48,;-9.1,-2.08,;-10.19,-3.17,;-9.5,-.6,;-8.41,.49,;1.08,.09,;1.08,-1.45,;2.41,-2.22,;3.75,-1.45,;5.08,-2.22,;6.42,-1.45,;7.9,-1.85,;8.3,-.36,;9.79,-.76,;10.19,.73,;8.7,1.13,;6.81,.04,;3.75,.09,;2.41,.86,)| Show InChI InChI=1S/C25H32N4O2/c26-23-22(24(31)28-20-6-8-21(30)9-7-20)12-19(13-27-23)18-4-2-17(3-5-18)14-29-15-25(16-29)10-1-11-25/h2-5,12-13,20-21,30H,1,6-11,14-16H2,(H2,26,27)(H,28,31)/t20-,21- | UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ... |
US Patent US10710980 (2020)
|
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451791
(US10710980, Example 23 | US10947218, Example 23)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(CN2CC3(CCC3)C2)cc1 |r,wU:10.10,wD:13.14,(-4.25,3.17,;-2.92,2.4,;-1.59,3.17,;-.25,2.4,;-.25,.86,;-1.59,.09,;-2.92,.86,;-4.25,.09,;-4.25,-1.45,;-5.59,.86,;-6.92,.09,;-6.52,-1.39,;-7.61,-2.48,;-9.1,-2.08,;-10.19,-3.17,;-9.5,-.6,;-8.41,.49,;1.08,.09,;1.08,-1.45,;2.41,-2.22,;3.75,-1.45,;5.08,-2.22,;6.42,-1.45,;7.9,-1.85,;8.3,-.36,;9.79,-.76,;10.19,.73,;8.7,1.13,;6.81,.04,;3.75,.09,;2.41,.86,)| Show InChI InChI=1S/C25H32N4O2/c26-23-22(24(31)28-20-6-8-21(30)9-7-20)12-19(13-27-23)18-4-2-17(3-5-18)14-29-15-25(16-29)10-1-11-25/h2-5,12-13,20-21,30H,1,6-11,14-16H2,(H2,26,27)(H,28,31)/t20-,21- | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (“1... |
US Patent US10710980 (2020)
|
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499,R206H]
(Homo sapiens (Human)) | BDBM451791
(US10710980, Example 23 | US10947218, Example 23)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(CN2CC3(CCC3)C2)cc1 |r,wU:10.10,wD:13.14,(-4.25,3.17,;-2.92,2.4,;-1.59,3.17,;-.25,2.4,;-.25,.86,;-1.59,.09,;-2.92,.86,;-4.25,.09,;-4.25,-1.45,;-5.59,.86,;-6.92,.09,;-6.52,-1.39,;-7.61,-2.48,;-9.1,-2.08,;-10.19,-3.17,;-9.5,-.6,;-8.41,.49,;1.08,.09,;1.08,-1.45,;2.41,-2.22,;3.75,-1.45,;5.08,-2.22,;6.42,-1.45,;7.9,-1.85,;8.3,-.36,;9.79,-.76,;10.19,.73,;8.7,1.13,;6.81,.04,;3.75,.09,;2.41,.86,)| Show InChI InChI=1S/C25H32N4O2/c26-23-22(24(31)28-20-6-8-21(30)9-7-20)12-19(13-27-23)18-4-2-17(3-5-18)14-29-15-25(16-29)10-1-11-25/h2-5,12-13,20-21,30H,1,6-11,14-16H2,(H2,26,27)(H,28,31)/t20-,21- | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (“1... |
US Patent US10710980 (2020)
|
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase receptor R3 [166-493]
(Homo sapiens (Human)) | BDBM451791
(US10710980, Example 23 | US10947218, Example 23)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(CN2CC3(CCC3)C2)cc1 |r,wU:10.10,wD:13.14,(-4.25,3.17,;-2.92,2.4,;-1.59,3.17,;-.25,2.4,;-.25,.86,;-1.59,.09,;-2.92,.86,;-4.25,.09,;-4.25,-1.45,;-5.59,.86,;-6.92,.09,;-6.52,-1.39,;-7.61,-2.48,;-9.1,-2.08,;-10.19,-3.17,;-9.5,-.6,;-8.41,.49,;1.08,.09,;1.08,-1.45,;2.41,-2.22,;3.75,-1.45,;5.08,-2.22,;6.42,-1.45,;7.9,-1.85,;8.3,-.36,;9.79,-.76,;10.19,.73,;8.7,1.13,;6.81,.04,;3.75,.09,;2.41,.86,)| Show InChI InChI=1S/C25H32N4O2/c26-23-22(24(31)28-20-6-8-21(30)9-7-20)12-19(13-27-23)18-4-2-17(3-5-18)14-29-15-25(16-29)10-1-11-25/h2-5,12-13,20-21,30H,1,6-11,14-16H2,(H2,26,27)(H,28,31)/t20-,21- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (“1... |
US Patent US10710980 (2020)
|
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1 [162-503]
(Homo sapiens (Human)) | BDBM451791
(US10710980, Example 23 | US10947218, Example 23)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(CN2CC3(CCC3)C2)cc1 |r,wU:10.10,wD:13.14,(-4.25,3.17,;-2.92,2.4,;-1.59,3.17,;-.25,2.4,;-.25,.86,;-1.59,.09,;-2.92,.86,;-4.25,.09,;-4.25,-1.45,;-5.59,.86,;-6.92,.09,;-6.52,-1.39,;-7.61,-2.48,;-9.1,-2.08,;-10.19,-3.17,;-9.5,-.6,;-8.41,.49,;1.08,.09,;1.08,-1.45,;2.41,-2.22,;3.75,-1.45,;5.08,-2.22,;6.42,-1.45,;7.9,-1.85,;8.3,-.36,;9.79,-.76,;10.19,.73,;8.7,1.13,;6.81,.04,;3.75,.09,;2.41,.86,)| Show InChI InChI=1S/C25H32N4O2/c26-23-22(24(31)28-20-6-8-21(30)9-7-20)12-19(13-27-23)18-4-2-17(3-5-18)14-29-15-25(16-29)10-1-11-25/h2-5,12-13,20-21,30H,1,6-11,14-16H2,(H2,26,27)(H,28,31)/t20-,21- | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (“1... |
US Patent US10710980 (2020)
|
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein receptor type-1B
(Homo sapiens (Human)) | BDBM451791
(US10710980, Example 23 | US10947218, Example 23)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(CN2CC3(CCC3)C2)cc1 |r,wU:10.10,wD:13.14,(-4.25,3.17,;-2.92,2.4,;-1.59,3.17,;-.25,2.4,;-.25,.86,;-1.59,.09,;-2.92,.86,;-4.25,.09,;-4.25,-1.45,;-5.59,.86,;-6.92,.09,;-6.52,-1.39,;-7.61,-2.48,;-9.1,-2.08,;-10.19,-3.17,;-9.5,-.6,;-8.41,.49,;1.08,.09,;1.08,-1.45,;2.41,-2.22,;3.75,-1.45,;5.08,-2.22,;6.42,-1.45,;7.9,-1.85,;8.3,-.36,;9.79,-.76,;10.19,.73,;8.7,1.13,;6.81,.04,;3.75,.09,;2.41,.86,)| Show InChI InChI=1S/C25H32N4O2/c26-23-22(24(31)28-20-6-8-21(30)9-7-20)12-19(13-27-23)18-4-2-17(3-5-18)14-29-15-25(16-29)10-1-11-25/h2-5,12-13,20-21,30H,1,6-11,14-16H2,(H2,26,27)(H,28,31)/t20-,21- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20... |
US Patent US10947218 (2021)
|
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451791
(US10710980, Example 23 | US10947218, Example 23)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(CN2CC3(CCC3)C2)cc1 |r,wU:10.10,wD:13.14,(-4.25,3.17,;-2.92,2.4,;-1.59,3.17,;-.25,2.4,;-.25,.86,;-1.59,.09,;-2.92,.86,;-4.25,.09,;-4.25,-1.45,;-5.59,.86,;-6.92,.09,;-6.52,-1.39,;-7.61,-2.48,;-9.1,-2.08,;-10.19,-3.17,;-9.5,-.6,;-8.41,.49,;1.08,.09,;1.08,-1.45,;2.41,-2.22,;3.75,-1.45,;5.08,-2.22,;6.42,-1.45,;7.9,-1.85,;8.3,-.36,;9.79,-.76,;10.19,.73,;8.7,1.13,;6.81,.04,;3.75,.09,;2.41,.86,)| Show InChI InChI=1S/C25H32N4O2/c26-23-22(24(31)28-20-6-8-21(30)9-7-20)12-19(13-27-23)18-4-2-17(3-5-18)14-29-15-25(16-29)10-1-11-25/h2-5,12-13,20-21,30H,1,6-11,14-16H2,(H2,26,27)(H,28,31)/t20-,21- | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49... |
US Patent US10947218 (2021)
|
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein receptor type-1A [198-525]
(Homo sapiens (Human)) | BDBM451791
(US10710980, Example 23 | US10947218, Example 23)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(CN2CC3(CCC3)C2)cc1 |r,wU:10.10,wD:13.14,(-4.25,3.17,;-2.92,2.4,;-1.59,3.17,;-.25,2.4,;-.25,.86,;-1.59,.09,;-2.92,.86,;-4.25,.09,;-4.25,-1.45,;-5.59,.86,;-6.92,.09,;-6.52,-1.39,;-7.61,-2.48,;-9.1,-2.08,;-10.19,-3.17,;-9.5,-.6,;-8.41,.49,;1.08,.09,;1.08,-1.45,;2.41,-2.22,;3.75,-1.45,;5.08,-2.22,;6.42,-1.45,;7.9,-1.85,;8.3,-.36,;9.79,-.76,;10.19,.73,;8.7,1.13,;6.81,.04,;3.75,.09,;2.41,.86,)| Show InChI InChI=1S/C25H32N4O2/c26-23-22(24(31)28-20-6-8-21(30)9-7-20)12-19(13-27-23)18-4-2-17(3-5-18)14-29-15-25(16-29)10-1-11-25/h2-5,12-13,20-21,30H,1,6-11,14-16H2,(H2,26,27)(H,28,31)/t20-,21- | UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49... |
US Patent US10947218 (2021)
|
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451791
(US10710980, Example 23 | US10947218, Example 23)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(CN2CC3(CCC3)C2)cc1 |r,wU:10.10,wD:13.14,(-4.25,3.17,;-2.92,2.4,;-1.59,3.17,;-.25,2.4,;-.25,.86,;-1.59,.09,;-2.92,.86,;-4.25,.09,;-4.25,-1.45,;-5.59,.86,;-6.92,.09,;-6.52,-1.39,;-7.61,-2.48,;-9.1,-2.08,;-10.19,-3.17,;-9.5,-.6,;-8.41,.49,;1.08,.09,;1.08,-1.45,;2.41,-2.22,;3.75,-1.45,;5.08,-2.22,;6.42,-1.45,;7.9,-1.85,;8.3,-.36,;9.79,-.76,;10.19,.73,;8.7,1.13,;6.81,.04,;3.75,.09,;2.41,.86,)| Show InChI InChI=1S/C25H32N4O2/c26-23-22(24(31)28-20-6-8-21(30)9-7-20)12-19(13-27-23)18-4-2-17(3-5-18)14-29-15-25(16-29)10-1-11-25/h2-5,12-13,20-21,30H,1,6-11,14-16H2,(H2,26,27)(H,28,31)/t20-,21- | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20... |
US Patent US10947218 (2021)
|
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499,R206H]
(Homo sapiens (Human)) | BDBM451791
(US10710980, Example 23 | US10947218, Example 23)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(CN2CC3(CCC3)C2)cc1 |r,wU:10.10,wD:13.14,(-4.25,3.17,;-2.92,2.4,;-1.59,3.17,;-.25,2.4,;-.25,.86,;-1.59,.09,;-2.92,.86,;-4.25,.09,;-4.25,-1.45,;-5.59,.86,;-6.92,.09,;-6.52,-1.39,;-7.61,-2.48,;-9.1,-2.08,;-10.19,-3.17,;-9.5,-.6,;-8.41,.49,;1.08,.09,;1.08,-1.45,;2.41,-2.22,;3.75,-1.45,;5.08,-2.22,;6.42,-1.45,;7.9,-1.85,;8.3,-.36,;9.79,-.76,;10.19,.73,;8.7,1.13,;6.81,.04,;3.75,.09,;2.41,.86,)| Show InChI InChI=1S/C25H32N4O2/c26-23-22(24(31)28-20-6-8-21(30)9-7-20)12-19(13-27-23)18-4-2-17(3-5-18)14-29-15-25(16-29)10-1-11-25/h2-5,12-13,20-21,30H,1,6-11,14-16H2,(H2,26,27)(H,28,31)/t20-,21- | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20... |
US Patent US10947218 (2021)
|
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase receptor R3 [166-493]
(Homo sapiens (Human)) | BDBM451791
(US10710980, Example 23 | US10947218, Example 23)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(CN2CC3(CCC3)C2)cc1 |r,wU:10.10,wD:13.14,(-4.25,3.17,;-2.92,2.4,;-1.59,3.17,;-.25,2.4,;-.25,.86,;-1.59,.09,;-2.92,.86,;-4.25,.09,;-4.25,-1.45,;-5.59,.86,;-6.92,.09,;-6.52,-1.39,;-7.61,-2.48,;-9.1,-2.08,;-10.19,-3.17,;-9.5,-.6,;-8.41,.49,;1.08,.09,;1.08,-1.45,;2.41,-2.22,;3.75,-1.45,;5.08,-2.22,;6.42,-1.45,;7.9,-1.85,;8.3,-.36,;9.79,-.76,;10.19,.73,;8.7,1.13,;6.81,.04,;3.75,.09,;2.41,.86,)| Show InChI InChI=1S/C25H32N4O2/c26-23-22(24(31)28-20-6-8-21(30)9-7-20)12-19(13-27-23)18-4-2-17(3-5-18)14-29-15-25(16-29)10-1-11-25/h2-5,12-13,20-21,30H,1,6-11,14-16H2,(H2,26,27)(H,28,31)/t20-,21- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20... |
US Patent US10947218 (2021)
|
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1 [162-503]
(Homo sapiens (Human)) | BDBM451791
(US10710980, Example 23 | US10947218, Example 23)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(CN2CC3(CCC3)C2)cc1 |r,wU:10.10,wD:13.14,(-4.25,3.17,;-2.92,2.4,;-1.59,3.17,;-.25,2.4,;-.25,.86,;-1.59,.09,;-2.92,.86,;-4.25,.09,;-4.25,-1.45,;-5.59,.86,;-6.92,.09,;-6.52,-1.39,;-7.61,-2.48,;-9.1,-2.08,;-10.19,-3.17,;-9.5,-.6,;-8.41,.49,;1.08,.09,;1.08,-1.45,;2.41,-2.22,;3.75,-1.45,;5.08,-2.22,;6.42,-1.45,;7.9,-1.85,;8.3,-.36,;9.79,-.76,;10.19,.73,;8.7,1.13,;6.81,.04,;3.75,.09,;2.41,.86,)| Show InChI InChI=1S/C25H32N4O2/c26-23-22(24(31)28-20-6-8-21(30)9-7-20)12-19(13-27-23)18-4-2-17(3-5-18)14-29-15-25(16-29)10-1-11-25/h2-5,12-13,20-21,30H,1,6-11,14-16H2,(H2,26,27)(H,28,31)/t20-,21- | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20... |
US Patent US10947218 (2021)
|
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein receptor type-1B
(Homo sapiens (Human)) | BDBM451791
(US10710980, Example 23 | US10947218, Example 23)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(CN2CC3(CCC3)C2)cc1 |r,wU:10.10,wD:13.14,(-4.25,3.17,;-2.92,2.4,;-1.59,3.17,;-.25,2.4,;-.25,.86,;-1.59,.09,;-2.92,.86,;-4.25,.09,;-4.25,-1.45,;-5.59,.86,;-6.92,.09,;-6.52,-1.39,;-7.61,-2.48,;-9.1,-2.08,;-10.19,-3.17,;-9.5,-.6,;-8.41,.49,;1.08,.09,;1.08,-1.45,;2.41,-2.22,;3.75,-1.45,;5.08,-2.22,;6.42,-1.45,;7.9,-1.85,;8.3,-.36,;9.79,-.76,;10.19,.73,;8.7,1.13,;6.81,.04,;3.75,.09,;2.41,.86,)| Show InChI InChI=1S/C25H32N4O2/c26-23-22(24(31)28-20-6-8-21(30)9-7-20)12-19(13-27-23)18-4-2-17(3-5-18)14-29-15-25(16-29)10-1-11-25/h2-5,12-13,20-21,30H,1,6-11,14-16H2,(H2,26,27)(H,28,31)/t20-,21- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (“1... |
US Patent US10710980 (2020)
|
More data for this
Ligand-Target Pair | |
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