Found 14 hits for monomerid = 451847 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451847
(US10710980, Example 75 | US10947218, Example 75)Show SMILES COCCN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:26.29,8.11,wD:29.33,6.6,(10.48,-4.95,;8.94,-4.95,;8.17,-3.62,;6.63,-3.62,;5.86,-2.29,;6.63,-.95,;5.6,.19,;4.35,1.1,;4.19,-.44,;4.35,-1.97,;2.86,.33,;1.52,-.44,;.19,.33,;.19,1.87,;1.52,2.64,;2.86,1.87,;-1.14,2.64,;-1.14,4.18,;-2.48,4.95,;-3.81,4.18,;-5.14,4.95,;-3.81,2.64,;-2.48,1.87,;-5.14,1.87,;-6.48,2.64,;-5.14,.33,;-6.48,-.44,;-6.48,-1.98,;-7.81,-2.75,;-9.14,-1.98,;-10.48,-2.75,;-9.14,-.44,;-7.81,.33,)| Show InChI InChI=1S/C26H34N4O3/c1-33-11-10-30-15-20-13-26(20,16-30)19-4-2-17(3-5-19)18-12-23(24(27)28-14-18)25(32)29-21-6-8-22(31)9-7-21/h2-5,12,14,20-22,31H,6-11,13,15-16H2,1H3,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ... |
US Patent US10710980 (2020)
BindingDB Entry DOI: 10.7270/Q2DF6V81 |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein receptor type-1A [198-525]
(Homo sapiens (Human)) | BDBM451847
(US10710980, Example 75 | US10947218, Example 75)Show SMILES COCCN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:26.29,8.11,wD:29.33,6.6,(10.48,-4.95,;8.94,-4.95,;8.17,-3.62,;6.63,-3.62,;5.86,-2.29,;6.63,-.95,;5.6,.19,;4.35,1.1,;4.19,-.44,;4.35,-1.97,;2.86,.33,;1.52,-.44,;.19,.33,;.19,1.87,;1.52,2.64,;2.86,1.87,;-1.14,2.64,;-1.14,4.18,;-2.48,4.95,;-3.81,4.18,;-5.14,4.95,;-3.81,2.64,;-2.48,1.87,;-5.14,1.87,;-6.48,2.64,;-5.14,.33,;-6.48,-.44,;-6.48,-1.98,;-7.81,-2.75,;-9.14,-1.98,;-10.48,-2.75,;-9.14,-.44,;-7.81,.33,)| Show InChI InChI=1S/C26H34N4O3/c1-33-11-10-30-15-20-13-26(20,16-30)19-4-2-17(3-5-19)18-12-23(24(27)28-14-18)25(32)29-21-6-8-22(31)9-7-21/h2-5,12,14,20-22,31H,6-11,13,15-16H2,1H3,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m1/s1 | UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ... |
US Patent US10710980 (2020)
BindingDB Entry DOI: 10.7270/Q2DF6V81 |
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451847
(US10710980, Example 75 | US10947218, Example 75)Show SMILES COCCN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:26.29,8.11,wD:29.33,6.6,(10.48,-4.95,;8.94,-4.95,;8.17,-3.62,;6.63,-3.62,;5.86,-2.29,;6.63,-.95,;5.6,.19,;4.35,1.1,;4.19,-.44,;4.35,-1.97,;2.86,.33,;1.52,-.44,;.19,.33,;.19,1.87,;1.52,2.64,;2.86,1.87,;-1.14,2.64,;-1.14,4.18,;-2.48,4.95,;-3.81,4.18,;-5.14,4.95,;-3.81,2.64,;-2.48,1.87,;-5.14,1.87,;-6.48,2.64,;-5.14,.33,;-6.48,-.44,;-6.48,-1.98,;-7.81,-2.75,;-9.14,-1.98,;-10.48,-2.75,;-9.14,-.44,;-7.81,.33,)| Show InChI InChI=1S/C26H34N4O3/c1-33-11-10-30-15-20-13-26(20,16-30)19-4-2-17(3-5-19)18-12-23(24(27)28-14-18)25(32)29-21-6-8-22(31)9-7-21/h2-5,12,14,20-22,31H,6-11,13,15-16H2,1H3,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (“1... |
US Patent US10710980 (2020)
BindingDB Entry DOI: 10.7270/Q2DF6V81 |
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499,R206H]
(Homo sapiens (Human)) | BDBM451847
(US10710980, Example 75 | US10947218, Example 75)Show SMILES COCCN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:26.29,8.11,wD:29.33,6.6,(10.48,-4.95,;8.94,-4.95,;8.17,-3.62,;6.63,-3.62,;5.86,-2.29,;6.63,-.95,;5.6,.19,;4.35,1.1,;4.19,-.44,;4.35,-1.97,;2.86,.33,;1.52,-.44,;.19,.33,;.19,1.87,;1.52,2.64,;2.86,1.87,;-1.14,2.64,;-1.14,4.18,;-2.48,4.95,;-3.81,4.18,;-5.14,4.95,;-3.81,2.64,;-2.48,1.87,;-5.14,1.87,;-6.48,2.64,;-5.14,.33,;-6.48,-.44,;-6.48,-1.98,;-7.81,-2.75,;-9.14,-1.98,;-10.48,-2.75,;-9.14,-.44,;-7.81,.33,)| Show InChI InChI=1S/C26H34N4O3/c1-33-11-10-30-15-20-13-26(20,16-30)19-4-2-17(3-5-19)18-12-23(24(27)28-14-18)25(32)29-21-6-8-22(31)9-7-21/h2-5,12,14,20-22,31H,6-11,13,15-16H2,1H3,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (“1... |
US Patent US10710980 (2020)
BindingDB Entry DOI: 10.7270/Q2DF6V81 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase receptor R3 [166-493]
(Homo sapiens (Human)) | BDBM451847
(US10710980, Example 75 | US10947218, Example 75)Show SMILES COCCN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:26.29,8.11,wD:29.33,6.6,(10.48,-4.95,;8.94,-4.95,;8.17,-3.62,;6.63,-3.62,;5.86,-2.29,;6.63,-.95,;5.6,.19,;4.35,1.1,;4.19,-.44,;4.35,-1.97,;2.86,.33,;1.52,-.44,;.19,.33,;.19,1.87,;1.52,2.64,;2.86,1.87,;-1.14,2.64,;-1.14,4.18,;-2.48,4.95,;-3.81,4.18,;-5.14,4.95,;-3.81,2.64,;-2.48,1.87,;-5.14,1.87,;-6.48,2.64,;-5.14,.33,;-6.48,-.44,;-6.48,-1.98,;-7.81,-2.75,;-9.14,-1.98,;-10.48,-2.75,;-9.14,-.44,;-7.81,.33,)| Show InChI InChI=1S/C26H34N4O3/c1-33-11-10-30-15-20-13-26(20,16-30)19-4-2-17(3-5-19)18-12-23(24(27)28-14-18)25(32)29-21-6-8-22(31)9-7-21/h2-5,12,14,20-22,31H,6-11,13,15-16H2,1H3,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (“1... |
US Patent US10710980 (2020)
BindingDB Entry DOI: 10.7270/Q2DF6V81 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1 [162-503]
(Homo sapiens (Human)) | BDBM451847
(US10710980, Example 75 | US10947218, Example 75)Show SMILES COCCN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:26.29,8.11,wD:29.33,6.6,(10.48,-4.95,;8.94,-4.95,;8.17,-3.62,;6.63,-3.62,;5.86,-2.29,;6.63,-.95,;5.6,.19,;4.35,1.1,;4.19,-.44,;4.35,-1.97,;2.86,.33,;1.52,-.44,;.19,.33,;.19,1.87,;1.52,2.64,;2.86,1.87,;-1.14,2.64,;-1.14,4.18,;-2.48,4.95,;-3.81,4.18,;-5.14,4.95,;-3.81,2.64,;-2.48,1.87,;-5.14,1.87,;-6.48,2.64,;-5.14,.33,;-6.48,-.44,;-6.48,-1.98,;-7.81,-2.75,;-9.14,-1.98,;-10.48,-2.75,;-9.14,-.44,;-7.81,.33,)| Show InChI InChI=1S/C26H34N4O3/c1-33-11-10-30-15-20-13-26(20,16-30)19-4-2-17(3-5-19)18-12-23(24(27)28-14-18)25(32)29-21-6-8-22(31)9-7-21/h2-5,12,14,20-22,31H,6-11,13,15-16H2,1H3,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (“1... |
US Patent US10710980 (2020)
BindingDB Entry DOI: 10.7270/Q2DF6V81 |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein receptor type-1B
(Homo sapiens (Human)) | BDBM451847
(US10710980, Example 75 | US10947218, Example 75)Show SMILES COCCN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:26.29,8.11,wD:29.33,6.6,(10.48,-4.95,;8.94,-4.95,;8.17,-3.62,;6.63,-3.62,;5.86,-2.29,;6.63,-.95,;5.6,.19,;4.35,1.1,;4.19,-.44,;4.35,-1.97,;2.86,.33,;1.52,-.44,;.19,.33,;.19,1.87,;1.52,2.64,;2.86,1.87,;-1.14,2.64,;-1.14,4.18,;-2.48,4.95,;-3.81,4.18,;-5.14,4.95,;-3.81,2.64,;-2.48,1.87,;-5.14,1.87,;-6.48,2.64,;-5.14,.33,;-6.48,-.44,;-6.48,-1.98,;-7.81,-2.75,;-9.14,-1.98,;-10.48,-2.75,;-9.14,-.44,;-7.81,.33,)| Show InChI InChI=1S/C26H34N4O3/c1-33-11-10-30-15-20-13-26(20,16-30)19-4-2-17(3-5-19)18-12-23(24(27)28-14-18)25(32)29-21-6-8-22(31)9-7-21/h2-5,12,14,20-22,31H,6-11,13,15-16H2,1H3,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20... |
US Patent US10947218 (2021)
BindingDB Entry DOI: 10.7270/Q24F1TVV |
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451847
(US10710980, Example 75 | US10947218, Example 75)Show SMILES COCCN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:26.29,8.11,wD:29.33,6.6,(10.48,-4.95,;8.94,-4.95,;8.17,-3.62,;6.63,-3.62,;5.86,-2.29,;6.63,-.95,;5.6,.19,;4.35,1.1,;4.19,-.44,;4.35,-1.97,;2.86,.33,;1.52,-.44,;.19,.33,;.19,1.87,;1.52,2.64,;2.86,1.87,;-1.14,2.64,;-1.14,4.18,;-2.48,4.95,;-3.81,4.18,;-5.14,4.95,;-3.81,2.64,;-2.48,1.87,;-5.14,1.87,;-6.48,2.64,;-5.14,.33,;-6.48,-.44,;-6.48,-1.98,;-7.81,-2.75,;-9.14,-1.98,;-10.48,-2.75,;-9.14,-.44,;-7.81,.33,)| Show InChI InChI=1S/C26H34N4O3/c1-33-11-10-30-15-20-13-26(20,16-30)19-4-2-17(3-5-19)18-12-23(24(27)28-14-18)25(32)29-21-6-8-22(31)9-7-21/h2-5,12,14,20-22,31H,6-11,13,15-16H2,1H3,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49... |
US Patent US10947218 (2021)
BindingDB Entry DOI: 10.7270/Q24F1TVV |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein receptor type-1A [198-525]
(Homo sapiens (Human)) | BDBM451847
(US10710980, Example 75 | US10947218, Example 75)Show SMILES COCCN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:26.29,8.11,wD:29.33,6.6,(10.48,-4.95,;8.94,-4.95,;8.17,-3.62,;6.63,-3.62,;5.86,-2.29,;6.63,-.95,;5.6,.19,;4.35,1.1,;4.19,-.44,;4.35,-1.97,;2.86,.33,;1.52,-.44,;.19,.33,;.19,1.87,;1.52,2.64,;2.86,1.87,;-1.14,2.64,;-1.14,4.18,;-2.48,4.95,;-3.81,4.18,;-5.14,4.95,;-3.81,2.64,;-2.48,1.87,;-5.14,1.87,;-6.48,2.64,;-5.14,.33,;-6.48,-.44,;-6.48,-1.98,;-7.81,-2.75,;-9.14,-1.98,;-10.48,-2.75,;-9.14,-.44,;-7.81,.33,)| Show InChI InChI=1S/C26H34N4O3/c1-33-11-10-30-15-20-13-26(20,16-30)19-4-2-17(3-5-19)18-12-23(24(27)28-14-18)25(32)29-21-6-8-22(31)9-7-21/h2-5,12,14,20-22,31H,6-11,13,15-16H2,1H3,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m1/s1 | UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49... |
US Patent US10947218 (2021)
BindingDB Entry DOI: 10.7270/Q24F1TVV |
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451847
(US10710980, Example 75 | US10947218, Example 75)Show SMILES COCCN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:26.29,8.11,wD:29.33,6.6,(10.48,-4.95,;8.94,-4.95,;8.17,-3.62,;6.63,-3.62,;5.86,-2.29,;6.63,-.95,;5.6,.19,;4.35,1.1,;4.19,-.44,;4.35,-1.97,;2.86,.33,;1.52,-.44,;.19,.33,;.19,1.87,;1.52,2.64,;2.86,1.87,;-1.14,2.64,;-1.14,4.18,;-2.48,4.95,;-3.81,4.18,;-5.14,4.95,;-3.81,2.64,;-2.48,1.87,;-5.14,1.87,;-6.48,2.64,;-5.14,.33,;-6.48,-.44,;-6.48,-1.98,;-7.81,-2.75,;-9.14,-1.98,;-10.48,-2.75,;-9.14,-.44,;-7.81,.33,)| Show InChI InChI=1S/C26H34N4O3/c1-33-11-10-30-15-20-13-26(20,16-30)19-4-2-17(3-5-19)18-12-23(24(27)28-14-18)25(32)29-21-6-8-22(31)9-7-21/h2-5,12,14,20-22,31H,6-11,13,15-16H2,1H3,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20... |
US Patent US10947218 (2021)
BindingDB Entry DOI: 10.7270/Q24F1TVV |
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499,R206H]
(Homo sapiens (Human)) | BDBM451847
(US10710980, Example 75 | US10947218, Example 75)Show SMILES COCCN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:26.29,8.11,wD:29.33,6.6,(10.48,-4.95,;8.94,-4.95,;8.17,-3.62,;6.63,-3.62,;5.86,-2.29,;6.63,-.95,;5.6,.19,;4.35,1.1,;4.19,-.44,;4.35,-1.97,;2.86,.33,;1.52,-.44,;.19,.33,;.19,1.87,;1.52,2.64,;2.86,1.87,;-1.14,2.64,;-1.14,4.18,;-2.48,4.95,;-3.81,4.18,;-5.14,4.95,;-3.81,2.64,;-2.48,1.87,;-5.14,1.87,;-6.48,2.64,;-5.14,.33,;-6.48,-.44,;-6.48,-1.98,;-7.81,-2.75,;-9.14,-1.98,;-10.48,-2.75,;-9.14,-.44,;-7.81,.33,)| Show InChI InChI=1S/C26H34N4O3/c1-33-11-10-30-15-20-13-26(20,16-30)19-4-2-17(3-5-19)18-12-23(24(27)28-14-18)25(32)29-21-6-8-22(31)9-7-21/h2-5,12,14,20-22,31H,6-11,13,15-16H2,1H3,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20... |
US Patent US10947218 (2021)
BindingDB Entry DOI: 10.7270/Q24F1TVV |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase receptor R3 [166-493]
(Homo sapiens (Human)) | BDBM451847
(US10710980, Example 75 | US10947218, Example 75)Show SMILES COCCN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:26.29,8.11,wD:29.33,6.6,(10.48,-4.95,;8.94,-4.95,;8.17,-3.62,;6.63,-3.62,;5.86,-2.29,;6.63,-.95,;5.6,.19,;4.35,1.1,;4.19,-.44,;4.35,-1.97,;2.86,.33,;1.52,-.44,;.19,.33,;.19,1.87,;1.52,2.64,;2.86,1.87,;-1.14,2.64,;-1.14,4.18,;-2.48,4.95,;-3.81,4.18,;-5.14,4.95,;-3.81,2.64,;-2.48,1.87,;-5.14,1.87,;-6.48,2.64,;-5.14,.33,;-6.48,-.44,;-6.48,-1.98,;-7.81,-2.75,;-9.14,-1.98,;-10.48,-2.75,;-9.14,-.44,;-7.81,.33,)| Show InChI InChI=1S/C26H34N4O3/c1-33-11-10-30-15-20-13-26(20,16-30)19-4-2-17(3-5-19)18-12-23(24(27)28-14-18)25(32)29-21-6-8-22(31)9-7-21/h2-5,12,14,20-22,31H,6-11,13,15-16H2,1H3,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20... |
US Patent US10947218 (2021)
BindingDB Entry DOI: 10.7270/Q24F1TVV |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1 [162-503]
(Homo sapiens (Human)) | BDBM451847
(US10710980, Example 75 | US10947218, Example 75)Show SMILES COCCN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:26.29,8.11,wD:29.33,6.6,(10.48,-4.95,;8.94,-4.95,;8.17,-3.62,;6.63,-3.62,;5.86,-2.29,;6.63,-.95,;5.6,.19,;4.35,1.1,;4.19,-.44,;4.35,-1.97,;2.86,.33,;1.52,-.44,;.19,.33,;.19,1.87,;1.52,2.64,;2.86,1.87,;-1.14,2.64,;-1.14,4.18,;-2.48,4.95,;-3.81,4.18,;-5.14,4.95,;-3.81,2.64,;-2.48,1.87,;-5.14,1.87,;-6.48,2.64,;-5.14,.33,;-6.48,-.44,;-6.48,-1.98,;-7.81,-2.75,;-9.14,-1.98,;-10.48,-2.75,;-9.14,-.44,;-7.81,.33,)| Show InChI InChI=1S/C26H34N4O3/c1-33-11-10-30-15-20-13-26(20,16-30)19-4-2-17(3-5-19)18-12-23(24(27)28-14-18)25(32)29-21-6-8-22(31)9-7-21/h2-5,12,14,20-22,31H,6-11,13,15-16H2,1H3,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20... |
US Patent US10947218 (2021)
BindingDB Entry DOI: 10.7270/Q24F1TVV |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein receptor type-1B
(Homo sapiens (Human)) | BDBM451847
(US10710980, Example 75 | US10947218, Example 75)Show SMILES COCCN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:26.29,8.11,wD:29.33,6.6,(10.48,-4.95,;8.94,-4.95,;8.17,-3.62,;6.63,-3.62,;5.86,-2.29,;6.63,-.95,;5.6,.19,;4.35,1.1,;4.19,-.44,;4.35,-1.97,;2.86,.33,;1.52,-.44,;.19,.33,;.19,1.87,;1.52,2.64,;2.86,1.87,;-1.14,2.64,;-1.14,4.18,;-2.48,4.95,;-3.81,4.18,;-5.14,4.95,;-3.81,2.64,;-2.48,1.87,;-5.14,1.87,;-6.48,2.64,;-5.14,.33,;-6.48,-.44,;-6.48,-1.98,;-7.81,-2.75,;-9.14,-1.98,;-10.48,-2.75,;-9.14,-.44,;-7.81,.33,)| Show InChI InChI=1S/C26H34N4O3/c1-33-11-10-30-15-20-13-26(20,16-30)19-4-2-17(3-5-19)18-12-23(24(27)28-14-18)25(32)29-21-6-8-22(31)9-7-21/h2-5,12,14,20-22,31H,6-11,13,15-16H2,1H3,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (“1... |
US Patent US10710980 (2020)
BindingDB Entry DOI: 10.7270/Q2DF6V81 |
More data for this
Ligand-Target Pair | |
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