BDBM452634 1-((3-((3R,5R)-5-(4- chlorophenyl)tetrahydro- furan-3-yl)-1,2,4- oxadiazol-5-yl)methyl)- 1H-imidazo[4,5-b] pyrazin-2-amine::US10710994, Example 112

SMILES: Nc1nc2nccnc2n1Cc1nc(no1)[C@@H]1CO[C@H](C1)c1ccc(Cl)cc1

InChI Key: InChIKey=OOABNTZYAYDDFY-WCQYABFASA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 452634   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM452634 (1-((3-((3R,5R)-5-(4- chlorophenyl)tetrahydro- fura...) Show SMILES Nc1nc2nccnc2n1Cc1nc(no1)[C@@H]1CO[C@H](C1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C18H16ClN7O2/c19-12-3-1-10(2-4-12)13-7-11(9-27-13)15-23-14(28-25-15)8-26-17-16(24-18(26)20)21-5-6-22-17/h1-6,11,13H,7-9H2,(H2,20,21,24)/t11-,13+/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...				US Patent US10710994 (2020)
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM452634 (1-((3-((3R,5R)-5-(4- chlorophenyl)tetrahydro- fura...) Show SMILES Nc1nc2nccnc2n1Cc1nc(no1)[C@@H]1CO[C@H](C1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C18H16ClN7O2/c19-12-3-1-10(2-4-12)13-7-11(9-27-13)15-23-14(28-25-15)8-26-17-16(24-18(26)20)21-5-6-22-17/h1-6,11,13H,7-9H2,(H2,20,21,24)/t11-,13+/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.8	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...				US Patent US10710994 (2020)
					More data for this Ligand-Target Pair