BDBM452671 2-amino-3-((3-((3R,5R)- 5-(4- chlorophenyl)tetrahydro- furan-3-yl)-1,2,4- oxadiazol-5-yl)methyl)- 7- (trifluoromethyl)imidazo [5,1-f][1,2,4]triazin- 4(3H)-one::US10710994, Example 149

SMILES: Nc1nn2c(ncc2c(=O)n1Cc1nc(no1)[C@@H]1CO[C@H](C1)c1ccc(Cl)cc1)C(F)(F)F

InChI Key: InChIKey=KDXRBPDHOHGHLI-GXFFZTMASA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 452671   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM452671 (2-amino-3-((3-((3R,5R)- 5-(4- chlorophenyl)tetrahy...) Show SMILES Nc1nn2c(ncc2c(=O)n1Cc1nc(no1)[C@@H]1CO[C@H](C1)c1ccc(Cl)cc1)C(F)(F)F |r| Show InChI InChI=1S/C19H15ClF3N7O3/c20-11-3-1-9(2-4-11)13-5-10(8-32-13)15-26-14(33-28-15)7-29-16(31)12-6-25-17(19(21,22)23)30(12)27-18(29)24/h1-4,6,10,13H,5,7-8H2,(H2,24,27)/t10-,13+/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...				US Patent US10710994 (2020)
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human))	BDBM452671 (2-amino-3-((3-((3R,5R)- 5-(4- chlorophenyl)tetrahy...) Show SMILES Nc1nn2c(ncc2c(=O)n1Cc1nc(no1)[C@@H]1CO[C@H](C1)c1ccc(Cl)cc1)C(F)(F)F |r| Show InChI InChI=1S/C19H15ClF3N7O3/c20-11-3-1-9(2-4-11)13-5-10(8-32-13)15-26-14(33-28-15)7-29-16(31)12-6-25-17(19(21,22)23)30(12)27-18(29)24/h1-4,6,10,13H,5,7-8H2,(H2,24,27)/t10-,13+/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.48	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ...				US Patent US10710994 (2020)
					More data for this Ligand-Target Pair