Found 5 hits for monomerid = 454584 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cyclin-dependent kinase 9
(Homo sapiens (Human)) | BDBM454584
(US10717746, Example 66)Show SMILES CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CCCCCc23)c(Cl)cn1 |r| Show InChI InChI=1S/C22H28ClN5O2/c1-14(29)26-16-7-5-6-15(10-16)22(30)27-21-11-17(19(23)13-24-21)18-12-25-28-9-4-2-3-8-20(18)28/h11-13,15-16H,2-10H2,1H3,(H,26,29)(H,24,27,30)/t15-,16+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB
US Patent
| Assay Description
Activity of CDK9 was determined in-vitro using a mobility shift assay on a Caliper LC3000 reader (Caliper/PerkinElmer), which measures fluorescence o... |
US Patent US10717746 (2020)
BindingDB Entry DOI: 10.7270/Q2NV9N9F |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 9
(Homo sapiens (Human)) | BDBM454584
(US10717746, Example 66)Show SMILES CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CCCCCc23)c(Cl)cn1 |r| Show InChI InChI=1S/C22H28ClN5O2/c1-14(29)26-16-7-5-6-15(10-16)22(30)27-21-11-17(19(23)13-24-21)18-12-25-28-9-4-2-3-8-20(18)28/h11-13,15-16H,2-10H2,1H3,(H,26,29)(H,24,27,30)/t15-,16+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB
US Patent
| Assay Description
Activity of CDK9 was determined in-vitro using a mobility shift assay on a Caliper LC3000 reader (Caliper/PerkinElmer), which measures fluorescence o... |
US Patent US10717746 (2020)
BindingDB Entry DOI: 10.7270/Q2NV9N9F |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 9
(Homo sapiens (Human)) | BDBM454584
(US10717746, Example 66)Show SMILES CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CCCCCc23)c(Cl)cn1 |r| Show InChI InChI=1S/C22H28ClN5O2/c1-14(29)26-16-7-5-6-15(10-16)22(30)27-21-11-17(19(23)13-24-21)18-12-25-28-9-4-2-3-8-20(18)28/h11-13,15-16H,2-10H2,1H3,(H,26,29)(H,24,27,30)/t15-,16+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 180 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01754
BindingDB Entry DOI: 10.7270/Q2M90D8V |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 9
(Homo sapiens (Human)) | BDBM454584
(US10717746, Example 66)Show SMILES CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CCCCCc23)c(Cl)cn1 |r| Show InChI InChI=1S/C22H28ClN5O2/c1-14(29)26-16-7-5-6-15(10-16)22(30)27-21-11-17(19(23)13-24-21)18-12-25-28-9-4-2-3-8-20(18)28/h11-13,15-16H,2-10H2,1H3,(H,26,29)(H,24,27,30)/t15-,16+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 92 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01754
BindingDB Entry DOI: 10.7270/Q2M90D8V |
More data for this
Ligand-Target Pair | |
Cyclin-T1/Cyclin-dependent kinase 9
(Homo sapiens (Human)) | BDBM454584
(US10717746, Example 66)Show SMILES CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CCCCCc23)c(Cl)cn1 |r| Show InChI InChI=1S/C22H28ClN5O2/c1-14(29)26-16-7-5-6-15(10-16)22(30)27-21-11-17(19(23)13-24-21)18-12-25-28-9-4-2-3-8-20(18)28/h11-13,15-16H,2-10H2,1H3,(H,26,29)(H,24,27,30)/t15-,16+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01754
BindingDB Entry DOI: 10.7270/Q2M90D8V |
More data for this
Ligand-Target Pair | |
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