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SMILES: Cc1c(ccc2nc(Cn3cc(cn3)C(=O)NCc3ncn4ccc(Br)cc34)cn12)C1CC1

InChI Key: InChIKey=AYZDCCSRKYCBED-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 454990   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasma kallikrein (Homo sapiens (Human))	BDBM454990 (US10730874, Compound I-14 | US11352356, Compound I...) Show SMILES Cc1c(ccc2nc(Cn3cc(cn3)C(=O)NCc3ncn4ccc(Br)cc34)cn12)C1CC1 Show InChI InChI=1S/C24H22BrN7O/c1-15-20(16-2-3-16)4-5-23-29-19(13-32(15)23)12-31-11-17(9-28-31)24(33)26-10-21-22-8-18(25)6-7-30(22)14-27-21/h4-9,11,13-14,16H,2-3,10,12H2,1H3,(H,26,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<1	n/a	n/a	n/a	n/a
TBA					Assay Description Example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing a fluorogenic peptide s...				Citation and Details BindingDB Entry DOI: 10.7270/Q2W95DCK
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM454990 (US10730874, Compound I-14 | US11352356, Compound I...) Show SMILES Cc1c(ccc2nc(Cn3cc(cn3)C(=O)NCc3ncn4ccc(Br)cc34)cn12)C1CC1 Show InChI InChI=1S/C24H22BrN7O/c1-15-20(16-2-3-16)4-5-23-29-19(13-32(15)23)12-31-11-17(9-28-31)24(33)26-10-21-22-8-18(25)6-7-30(22)14-27-21/h4-9,11,13-14,16H,2-3,10,12H2,1H3,(H,26,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<1	n/a	n/a	n/a	n/a
Shire Human Genetic Therapies, Inc. US Patent					Assay Description Example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing a fluorogenic peptide s...				US Patent US10730874 (2020) BindingDB Entry DOI: 10.7270/Q2RN3BXC
					More data for this Ligand-Target Pair