null

SMILES: CCOC(=O)COc1cc(cn2cc(Cn3cc(nn3)C(=O)NCc3ncn4ccc(Cl)c(F)c34)nc12)C1CC1

InChI Key: InChIKey=FWUDJTOFXCGHCR-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 455189   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasma kallikrein (Homo sapiens (Human))	BDBM455189 (US10730874, Compound I-207 | US11352356, Compound ...) Show SMILES CCOC(=O)COc1cc(cn2cc(Cn3cc(nn3)C(=O)NCc3ncn4ccc(Cl)c(F)c34)nc12)C1CC1 Show InChI InChI=1S/C26H24ClFN8O4/c1-2-39-22(37)13-40-21-7-16(15-3-4-15)9-35-10-17(31-25(21)35)11-36-12-20(32-33-36)26(38)29-8-19-24-23(28)18(27)5-6-34(24)14-30-19/h5-7,9-10,12,14-15H,2-4,8,11,13H2,1H3,(H,29,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	n/a	<1	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM455189 (US10730874, Compound I-207 | US11352356, Compound ...) Show SMILES CCOC(=O)COc1cc(cn2cc(Cn3cc(nn3)C(=O)NCc3ncn4ccc(Cl)c(F)c34)nc12)C1CC1 Show InChI InChI=1S/C26H24ClFN8O4/c1-2-39-22(37)13-40-21-7-16(15-3-4-15)9-35-10-17(31-25(21)35)11-36-12-20(32-33-36)26(38)29-8-19-24-23(28)18(27)5-6-34(24)14-30-19/h5-7,9-10,12,14-15H,2-4,8,11,13H2,1H3,(H,29,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<1	n/a	n/a	n/a	n/a
Shire Human Genetic Therapies, Inc. US Patent					Assay Description Example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing a fluorogenic peptide s...				US Patent US10730874 (2020)
					More data for this Ligand-Target Pair