null

SMILES: Fc1c(Cl)ccn2cnc(CNC(=O)c3cnn(Cc4cn5cc(cc(Cc6nnco6)c5n4)C4CC4)c3)c12

InChI Key: InChIKey=QBAIWYMONSAABV-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 455197   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasma kallikrein (Homo sapiens (Human))	BDBM455197 (US10730874, Compound I-214 | US11352356, Compound ...) Show SMILES Fc1c(Cl)ccn2cnc(CNC(=O)c3cnn(Cc4cn5cc(cc(Cc6nnco6)c5n4)C4CC4)c3)c12 Show InChI InChI=1S/C26H21ClFN9O2/c27-20-3-4-35-13-30-21(24(35)23(20)28)8-29-26(38)18-7-32-37(10-18)12-19-11-36-9-17(15-1-2-15)5-16(25(36)33-19)6-22-34-31-14-39-22/h3-5,7,9-11,13-15H,1-2,6,8,12H2,(H,29,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<1	n/a	n/a	n/a	n/a
TBA					Assay Description Example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing a fluorogenic peptide s...				Citation and Details BindingDB Entry DOI: 10.7270/Q2W95DCK
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM455197 (US10730874, Compound I-214 | US11352356, Compound ...) Show SMILES Fc1c(Cl)ccn2cnc(CNC(=O)c3cnn(Cc4cn5cc(cc(Cc6nnco6)c5n4)C4CC4)c3)c12 Show InChI InChI=1S/C26H21ClFN9O2/c27-20-3-4-35-13-30-21(24(35)23(20)28)8-29-26(38)18-7-32-37(10-18)12-19-11-36-9-17(15-1-2-15)5-16(25(36)33-19)6-22-34-31-14-39-22/h3-5,7,9-11,13-15H,1-2,6,8,12H2,(H,29,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<1	n/a	n/a	n/a	n/a
Shire Human Genetic Therapies, Inc. US Patent					Assay Description Example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing a fluorogenic peptide s...				US Patent US10730874 (2020) BindingDB Entry DOI: 10.7270/Q2RN3BXC
					More data for this Ligand-Target Pair