null

SMILES: Fc1c(Cl)ccn2cnc(CNC(=O)c3cn(Cc4cn5cc(cc(N6CCOC6=O)c5n4)C4CC4)nn3)c12

InChI Key: InChIKey=QOZPQJGJKRLSPV-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 455199   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasma kallikrein (Homo sapiens (Human))	BDBM455199 (US10730874, Compound I-216 | US11352356, Compound ...) Show SMILES Fc1c(Cl)ccn2cnc(CNC(=O)c3cn(Cc4cn5cc(cc(N6CCOC6=O)c5n4)C4CC4)nn3)c12 Show InChI InChI=1S/C25H21ClFN9O3/c26-17-3-4-33-13-29-18(22(33)21(17)27)8-28-24(37)19-12-35(32-31-19)11-16-10-34-9-15(14-1-2-14)7-20(23(34)30-16)36-5-6-39-25(36)38/h3-4,7,9-10,12-14H,1-2,5-6,8,11H2,(H,28,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	n/a	<1	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2W95DCK
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM455199 (US10730874, Compound I-216 | US11352356, Compound ...) Show SMILES Fc1c(Cl)ccn2cnc(CNC(=O)c3cn(Cc4cn5cc(cc(N6CCOC6=O)c5n4)C4CC4)nn3)c12 Show InChI InChI=1S/C25H21ClFN9O3/c26-17-3-4-33-13-29-18(22(33)21(17)27)8-28-24(37)19-12-35(32-31-19)11-16-10-34-9-15(14-1-2-14)7-20(23(34)30-16)36-5-6-39-25(36)38/h3-4,7,9-10,12-14H,1-2,5-6,8,11H2,(H,28,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<1	n/a	n/a	n/a	n/a
Shire Human Genetic Therapies, Inc. US Patent					Assay Description Example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing a fluorogenic peptide s...				US Patent US10730874 (2020) BindingDB Entry DOI: 10.7270/Q2RN3BXC
					More data for this Ligand-Target Pair