null

SMILES: OC(=O)c1cn(cn1)-c1cc(cn2cc(Cn3cc(nn3)C(=O)NCc3ncn4ccc(Cl)c(F)c34)nc12)C1CC1

InChI Key: InChIKey=UTYNLOXXNUTIPN-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 455212   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasma kallikrein (Homo sapiens (Human))	BDBM455212 (US10730874, Compound I-226 | US11352356, Compound ...) Show SMILES OC(=O)c1cn(cn1)-c1cc(cn2cc(Cn3cc(nn3)C(=O)NCc3ncn4ccc(Cl)c(F)c34)nc12)C1CC1 Show InChI InChI=1S/C26H20ClFN10O3/c27-17-3-4-35-12-30-18(23(35)22(17)28)6-29-25(39)19-11-38(34-33-19)9-16-8-36-7-15(14-1-2-14)5-21(24(36)32-16)37-10-20(26(40)41)31-13-37/h3-5,7-8,10-14H,1-2,6,9H2,(H,29,39)(H,40,41)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<1	n/a	n/a	n/a	n/a
TBA					Assay Description Example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing a fluorogenic peptide s...				Citation and Details BindingDB Entry DOI: 10.7270/Q2W95DCK
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM455212 (US10730874, Compound I-226 | US11352356, Compound ...) Show SMILES OC(=O)c1cn(cn1)-c1cc(cn2cc(Cn3cc(nn3)C(=O)NCc3ncn4ccc(Cl)c(F)c34)nc12)C1CC1 Show InChI InChI=1S/C26H20ClFN10O3/c27-17-3-4-35-12-30-18(23(35)22(17)28)6-29-25(39)19-11-38(34-33-19)9-16-8-36-7-15(14-1-2-14)5-21(24(36)32-16)37-10-20(26(40)41)31-13-37/h3-5,7-8,10-14H,1-2,6,9H2,(H,29,39)(H,40,41)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<1	n/a	n/a	n/a	n/a
Shire Human Genetic Therapies, Inc. US Patent					Assay Description Example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing a fluorogenic peptide s...				US Patent US10730874 (2020) BindingDB Entry DOI: 10.7270/Q2RN3BXC
					More data for this Ligand-Target Pair