null

SMILES: Fc1c(Cl)ccn2cnc(CNC(=O)c3cn(Cc4cc5ccc(Cl)cc5s4)nn3)c12

InChI Key: InChIKey=UDQXMMRHILVFQM-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 455221   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasma kallikrein (Homo sapiens (Human))	BDBM455221 (US10730874, Compound I-234 | US11352356, Compound ...) Show SMILES Fc1c(Cl)ccn2cnc(CNC(=O)c3cn(Cc4cc5ccc(Cl)cc5s4)nn3)c12 Show InChI InChI=1S/C20H13Cl2FN6OS/c21-12-2-1-11-5-13(31-17(11)6-12)8-29-9-16(26-27-29)20(30)24-7-15-19-18(23)14(22)3-4-28(19)10-25-15/h1-6,9-10H,7-8H2,(H,24,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	n/a	55	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2W95DCK
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM455221 (US10730874, Compound I-234 | US11352356, Compound ...) Show SMILES Fc1c(Cl)ccn2cnc(CNC(=O)c3cn(Cc4cc5ccc(Cl)cc5s4)nn3)c12 Show InChI InChI=1S/C20H13Cl2FN6OS/c21-12-2-1-11-5-13(31-17(11)6-12)8-29-9-16(26-27-29)20(30)24-7-15-19-18(23)14(22)3-4-28(19)10-25-15/h1-6,9-10H,7-8H2,(H,24,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	55	n/a	n/a	n/a	n/a
Shire Human Genetic Therapies, Inc. US Patent					Assay Description Example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing a fluorogenic peptide s...				US Patent US10730874 (2020) BindingDB Entry DOI: 10.7270/Q2RN3BXC
					More data for this Ligand-Target Pair