BDBM455230 US10730874, Compound I-242
SMILES: CCn1ncn(-c2cc(cn3cc(Cn4cc(nn4)C(=O)NCc4ncn5ccc(Cl)c(F)c45)nc23)C2CC2)c(=O)c1=O
InChI Key: InChIKey=XPDLVYUDGVDSQA-UHFFFAOYSA-N
Data: 1 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Plasma kallikrein (Homo sapiens (Human)) | BDBM455230 (US10730874, Compound I-242) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <1 | n/a | n/a | n/a | n/a |
Shire Human Genetic Therapies, Inc. US Patent | Assay Description Example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing a fluorogenic peptide s... | US Patent US10730874 (2020) | |||||||||||
More data for this Ligand-Target Pair |